Reprogramming methanol utilization pathways to convert Saccharomyces cerevisiae to a synthetic methylotroph

C Zhan, X Li, G Lan, EEK Baidoo, Y Yang, Y Liu… - Nature Catalysis, 2023 - nature.com
Methanol, an organic one-carbon (C1) compound, represents an attractive alternative
carbon source for microbial fermentation. Despite considerable advancements in methanol …

The wide‐ranging phenotypes of ergosterol biosynthesis mutants, and implications for microbial cell factories

EJ Johnston, T Moses, SJ Rosser - Yeast, 2020 - Wiley Online Library
Yeast strains have been used extensively as robust microbial cell factories for the production
of bulk and fine chemicals, including biofuels (bioethanol), complex pharmaceuticals …

Characterization and Role of Sterols in Saccharomyces cerevisiae during White Wine Alcoholic Fermentation

G Girardi Piva, E Casalta, JL Legras, C Tesnière… - Fermentation, 2022 - mdpi.com
Responsible for plasma membrane structure maintenance in eukaryotic organisms, sterols
are essential for yeast development. The role of two sterol sources in Saccharomyces …

Engineering membrane architecture for biotechnological applications

Z Jin, A Vighi, Y Dong, JA Bureau, C Ignea - Biotechnology Advances, 2023 - Elsevier
Cellular membranes, predominantly described as a dynamic bilayer, are composed of
different lipids, transmembrane proteins, and carbohydrates. Most research on biological …

Yeast as a promising heterologous host for steroid bioproduction

S Xu, Y Li - Journal of Industrial Microbiology & Biotechnology …, 2020 - academic.oup.com
With the rapid development of synthetic biology and metabolic engineering technologies,
yeast has been generally considered as promising hosts for the bioproduction of secondary …

Metabolic engineering strategies for de novo biosynthesis of sterols and steroids in yeast

Y Gu, X Jiao, L Ye, H Yu - Bioresources and Bioprocessing, 2021 - Springer
Steroidal compounds are of great interest in the pharmaceutical field, with steroidal drugs as
the second largest category of medicine in the world. Advances in synthetic biology and …

[HTML][HTML] Selection and subsequent physiological characterization of industrial Saccharomyces cerevisiae strains during continuous growth at sub-and-supra optimal …

KYF Lip, E García-Ríos, CE Costa, JM Guillamón… - Biotechnology …, 2020 - Elsevier
A phenotypic screening of 12 industrial yeast strains and the well-studied laboratory strain
CEN. PK113-7D at cultivation temperatures between 12° C and 40° C revealed significant …

Ergosterol turnover in yeast: an interplay between biosynthesis and transport

SS Sokolov, NI Trushina, FF Severin, DA Knorre - Biochemistry (Moscow), 2019 - Springer
Sterols are important components of biological membranes that determine the
physicochemical properties of lipid bilayer and regulate the functioning of membrane …

An expanded toolkit of drug resistance cassettes for Candida glabrata, Candida auris, and Candida albicans leads to new insights into the ergosterol pathway

JB Gregor, VA Gutierrez-Schultz, S Hoda, KM Baker… - Msphere, 2023 - Am Soc Microbiol
ABSTRACT The World Health Organization recently published the first list of priority fungal
pathogens highlighting multiple Candida species, including Candida glabrata, Candida …

Thermotolerance improvement of engineered Saccharomyces cerevisiae ERG5 Delta ERG4 Delta ERG3 Delta, molecular mechanism, and its application in corn …

P Yang, W Wu, J Chen, S Jiang, Z Zheng… - … for Biofuels and …, 2023 - Springer
Background The thermotolerant yeast is beneficial in terms of efficiency improvement of
processes and reduction of costs, while Saccharomyces cerevisiae does not efficiently grow …