Type 2 diabetes mellitus is a progressive disease that is characterized by the appearance of
insulin resistance. The term insulin resistance is very wide and could affect different proteins …

Autophagy is a highly conserved process that degrades certain intracellular contents in both
physiological and pathological conditions. Autophagy-related proteins (ATG) are key players …

Type 2 diabetes (T2D) is one of the main current threats to human health. Both T2D and its
numerous clinical complications are related to mitochondrial dysfunction and oxidative …

The mechanistic target of rapamycin complex 1 (mTORC1) is a central regulator of metabolic
and nutrient cues that integrates environmental inputs into downstream signaling pathways …

Autophagy, an intracellular conserved degradative process, plays a central role in the
renewal/recycling of a cell to maintain the homeostasis of nutrients and energy within the …

Three principal ER quality-control mechanisms, namely, the unfolded protein response, ER-
associated degradation (ERAD), and ER-phagy are each important for the maintenance of …

Deregulation of mTOR complex 1 (mTORC1) signalling increases the risk for metabolic
diseases, including type 2 diabetes. Here we show that β-cell-specific loss of mTORC1 …

Background Elucidation of the basic molecular mechanism of autophagy was a
breakthrough in understanding various physiological events and pathogenesis of diverse …

Insulin secretion is critical for glucose homeostasis, and increased levels of the precursor
proinsulin relative to insulin indicate pancreatic islet beta-cell stress and insufficient insulin …

We show here that human pancreatic islets highly express C3, which is both secreted and
present in the cytosol. Within isolated human islets, C3 expression correlates with type 2 …