Gut microbiota influence immunotherapy responses: mechanisms and therapeutic strategies

Y Lu, X Yuan, M Wang, Z He, H Li, J Wang… - Journal of hematology & …, 2022 - Springer
The gut microbiota have long been recognized to play a key role in human health and
disease. Currently, several lines of evidence from preclinical to clinical research have …

Targeting the gut microbiota for cancer therapy

MR Fernandes, P Aggarwal, RGF Costa… - Nature Reviews …, 2022 - nature.com
Growing evidence suggests that the gut microbiota modulates the efficacy and toxicity of
cancer therapy, most notably immunotherapy and its immune-related adverse effects. The …

Microbiome-derived inosine modulates response to checkpoint inhibitor immunotherapy

LF Mager, R Burkhard, N Pett, NCA Cooke, K Brown… - Science, 2020 - science.org
Several species of intestinal bacteria have been associated with enhanced efficacy of
checkpoint blockade immunotherapy, but the underlying mechanisms by which the …

Interaction between microbiota and immunity in health and disease

D Zheng, T Liwinski, E Elinav - Cell research, 2020 - nature.com
The interplay between the commensal microbiota and the mammalian immune system
development and function includes multifold interactions in homeostasis and disease. The …

You are what you eat: diet, health and the gut microbiota

N Zmora, J Suez, E Elinav - Nature reviews Gastroenterology & …, 2019 - nature.com
Since the renaissance of microbiome research in the past decade, much insight has
accumulated in comprehending forces shaping the architecture and functionality of resident …

The adenosine pathway in immuno-oncology

B Allard, D Allard, L Buisseret, J Stagg - Nature Reviews Clinical …, 2020 - nature.com
Cancer immunotherapy based on immune-checkpoint inhibition or adoptive cell therapy has
revolutionized cancer care. Nevertheless, a large proportion of patients do not benefit from …

Role of Lactobacillus reuteri in Human Health and Diseases

Q Mu, VJ Tavella, XM Luo - Frontiers in microbiology, 2018 - frontiersin.org
Lactobacillus reuteri (L. reuteri) is a well-studied probiotic bacterium that can colonize a
large number of mammals. In humans, L. reuteri is found in different body sites, including the …

A review of gut microbiota‐derived metabolites in tumor progression and cancer therapy

Q Yang, B Wang, Q Zheng, H Li, X Meng… - Advanced …, 2023 - Wiley Online Library
Gut microbiota‐derived metabolites are key hubs connecting the gut microbiome and cancer
progression, primarily by remodeling the tumor microenvironment and regulating key …

Defining the role of Parasutterella, a previously uncharacterized member of the core gut microbiota

T Ju, JY Kong, P Stothard, BP Willing - The ISME journal, 2019 - academic.oup.com
The genus of Parasutterella has been defined as a core component of the human and
mouse gut microbiota, and has been correlated with various health outcomes. However, like …

Gut microbiota-derived inosine from dietary barley leaf supplementation attenuates colitis through PPARγ signaling activation

D Li, Y Feng, M Tian, J Ji, X Hu, F Chen - Microbiome, 2021 - Springer
Background Ulcerative colitis is a type of chronic inflammatory bowel disease closely
associated with gut microbiota dysbiosis and intestinal homeostasis dysregulation. Barley …