Erythropoietin: emerging role of erythropoietin in neonatal neuroprotection

V Rangarajan, SE Juul - Pediatric neurology, 2014 - Elsevier
Background In the last two decades, there has been considerable evolution in
understanding the role of erythropoietin in neuroprotection. Erythropoietin has both …

Erythropoietin action in stress response, tissue maintenance and metabolism

Y Zhang, L Wang, S Dey, M Alnaeeli, S Suresh… - International journal of …, 2014 - mdpi.com
Erythropoietin (EPO) regulation of red blood cell production and its induction at reduced
oxygen tension provides for the important erythropoietic response to ischemic stress. The …

Standardized environmental enrichment supports enhanced brain plasticity in healthy rats and prevents cognitive impairment in epileptic rats

RP Fares, A Belmeguenai, PE Sanchez, HY Kouchi… - PloS one, 2013 - journals.plos.org
Environmental enrichment of laboratory animals influences brain plasticity, stimulates
neurogenesis, increases neurotrophic factor expression, and protects against the effects of …

Erythropoietin as neuroprotective and neuroregenerative treatment strategy: comprehensive overview of 12 years of preclinical and clinical research

D Sargin, H Friedrichs, A El-Kordi… - Best practice & research …, 2010 - Elsevier
Erythropoietin (EPO), originally discovered as hematopoietic growth factor, has direct effects
on cells of the nervous system that make it a highly attractive candidate drug for …

Retinal pigment epithelium-secretome: A diabetic retinopathy perspective

M Ponnalagu, M Subramani, C Jayadev, R Shetty… - Cytokine, 2017 - Elsevier
Diabetic retinopathy is a major complication of diabetes mellitus that can lead to retinal
vascular abnormalities and visual impairment. While retinal endothelial pathology is well …

The effect of erythropoietin on normal and neoplastic cells

S Elliott, AM Sinclair - Biologics: Targets and Therapy, 2012 - Taylor & Francis
Erythropoietin (Epo) is an essential hormone that binds and activates the Epo receptor
(EpoR) resident on the surface of erythroid progenitor cells, thereby promoting …

Oxidative stress: Biomarkers and novel therapeutic pathways

K Maiese, ZZ Chong, J Hou, YC Shang - Experimental gerontology, 2010 - Elsevier
Oxidative stress significantly impacts multiple cellular pathways that can lead to the initiation
and progression of varied disorders throughout the body. It therefore becomes imperative to …

Neuroplasticity and the next wave of antidepressant strategies

S Hayley, D Litteljohn - Frontiers in cellular neuroscience, 2013 - frontiersin.org
Depression is a common chronic psychiatric disorder that is also often co-morbid with
numerous neurological and immune diseases. Accumulating evidence indicates that …

Introducing the brain erythropoietin circle to explain adaptive brain hardware upgrade and improved performance

H Ehrenreich, LF Garcia-Agudo… - Molecular …, 2022 - nature.com
Preface Executive functions, learning, attention, and processing speed are imperative facets
of cognitive performance, affected in neuropsychiatric disorders. In clinical studies on …

Erythropoietin for neonatal brain injury: opportunity and challenge

T Xiong, Y Qu, D Mu, D Ferriero - International Journal of Developmental …, 2011 - Elsevier
Neonatal brain injury, caused by perinatal hypoxia-ischemia and extreme prematurity,
remains a great challenge for prevention and treatment. There is no effective treatment for …