Central nervous system effects of 5-HT7 receptors: a potential target for neurodegenerative diseases
A Quintero-Villegas, SI Valdés-Ferrer - Molecular Medicine, 2022 - Springer
HT7 receptors (5-HT7R) are the most recently identified among the family of serotonin
receptors. Their role in health and disease, particularly as mediators of, and druggable …
receptors. Their role in health and disease, particularly as mediators of, and druggable …
[HTML][HTML] Recent advances in the design and development of formyl peptide receptor 2 (FPR2/ALX) agonists as pro-resolving agents with diverse therapeutic potential
Under physiological conditions the initiation, duration and amplitude of inflammatory
responses are tightly regulated to ensure the restoration of homeostasis. The resolution of …
responses are tightly regulated to ensure the restoration of homeostasis. The resolution of …
Role of the serotonin receptor 7 in brain plasticity: From development to disease
Our knowledge on the plastic functions of the serotonin (5-HT) receptor subtype 7 (5-HT7R)
in the brain physiology and pathology have advanced considerably in recent years. A wealth …
in the brain physiology and pathology have advanced considerably in recent years. A wealth …
Structure–Activity Relationships and Therapeutic Potentials of 5-HT7 Receptor Ligands: An Update
MN Modica, E Lacivita, S Intagliata… - Journal of Medicinal …, 2018 - ACS Publications
Serotonin 5-HT7 receptor (5-HT7R) has been the subject of intense research efforts
because of its presence in brain areas such as the hippocampus, hypothalamus, and cortex …
because of its presence in brain areas such as the hippocampus, hypothalamus, and cortex …
Novel ureidopropanamide based N-formyl peptide receptor 2 (FPR2) agonists with potential application for central nervous system disorders characterized by …
ML Stama, J Ślusarczyk, E Lacivita, LN Kirpotina… - European journal of …, 2017 - Elsevier
Abstract Formyl peptide receptor2 (FPR2) is a G-protein coupled receptor that plays critical
roles in inflammatory reactions. FPR2-specific interaction can be possibly used to facilitate …
roles in inflammatory reactions. FPR2-specific interaction can be possibly used to facilitate …
Knowledge-based design of long-chain arylpiperazine derivatives targeting multiple serotonin receptors as potential candidates for treatment of autism spectrum …
E Lacivita, M Niso, M Mastromarino… - ACS Chemical …, 2021 - ACS Publications
Autism spectrum disorder (ASD) includes a group of neurodevelopmental disorders
characterized by core symptoms such as impaired social interaction and communication …
characterized by core symptoms such as impaired social interaction and communication …
Search for a 5-CT alternative. In vitro and in vivo evaluation of novel pharmacological tools: 3-(1-alkyl-1 H-imidazol-5-yl)-1 H-indole-5-carboxamides, low-basicity 5-HT …
Close structural analogues of 5-carboxamidotryptamine (5-CT) based on the newly
discovered indole–imidazole scaffold were synthesized and evaluated to search for a 5-HT7 …
discovered indole–imidazole scaffold were synthesized and evaluated to search for a 5-HT7 …
Fluorinated indole-imidazole conjugates: Selective orally bioavailable 5-HT7 receptor low-basicity agonists, potential neuropathic painkillers
AS Hogendorf, A Hogendorf, K Popiołek-Barczyk… - European Journal of …, 2019 - Elsevier
The 5-HT 7 receptor has recently gained much attention due to its involvement in multiple
physiological functions and diseases. The insufficient quality of the available molecular …
physiological functions and diseases. The insufficient quality of the available molecular …
Privileged scaffold-based design to identify a novel drug-like 5-HT7 receptor-preferring agonist to target Fragile X syndrome
E Lacivita, M Niso, ML Stama, A Arzuaga… - European journal of …, 2020 - Elsevier
Recent preclinical studies have shown that activation of the serotonin 5-HT 7 receptor has
the potential to treat neurodevelopmental disorders such as Fragile X syndrome, a rare …
the potential to treat neurodevelopmental disorders such as Fragile X syndrome, a rare …
Low-basicity 5-HT7 Receptor Agonists Synthesized Using the van Leusen Multicomponent Protocol
Abstract A series of 5-aryl-1-alkylimidazole derivatives was synthesized using the van
Leusen multicomponent reaction. The chemotype is the first example of low-basicity …
Leusen multicomponent reaction. The chemotype is the first example of low-basicity …