Molecular basis of atrial fibrillation pathophysiology and therapy: a translational perspective
Atrial fibrillation (AF) is a highly prevalent arrhythmia, with substantial associated morbidity
and mortality. There have been significant management advances over the past 2 decades …
and mortality. There have been significant management advances over the past 2 decades …
Atrial remodeling and atrial fibrillation: recent advances and translational perspectives
S Nattel, M Harada - Journal of the American College of Cardiology, 2014 - jacc.org
Atrial fibrillation (AF) is the most common sustained arrhythmia in clinical practice. AF and its
complications are responsible for important population morbidity and mortality. Presently …
complications are responsible for important population morbidity and mortality. Presently …
Animal models of arrhythmia: classic electrophysiology to genetically modified large animals
S Clauss, C Bleyer, D Schuettler, P Tomsits… - Nature Reviews …, 2019 - nature.com
Arrhythmias are common and contribute substantially to cardiovascular morbidity and
mortality. The underlying pathophysiology of arrhythmias is complex and remains …
mortality. The underlying pathophysiology of arrhythmias is complex and remains …
Animal models of atrial fibrillation
D Schüttler, A Bapat, S Kääb, K Lee, P Tomsits… - Circulation …, 2020 - Am Heart Assoc
Atrial fibrillation (AF) is the most common sustained arrhythmia encountered in humans and
is a significant source of morbidity and mortality. Despite its prevalence, our mechanistic …
is a significant source of morbidity and mortality. Despite its prevalence, our mechanistic …
Translational challenges in atrial fibrillation
Atrial fibrillation (AF) is the most common sustained heart rhythm disorder and is associated
with substantial morbidity and mortality. Current treatment options for AF have significant …
with substantial morbidity and mortality. Current treatment options for AF have significant …
Atrial fibrillation promotion with long-term repetitive obstructive sleep apnea in a rat model
Y Iwasaki, T Kato, F Xiong, YF Shi, P Naud… - Journal of the American …, 2014 - jacc.org
Background: Obstructive sleep apnea (OSA) importantly contributes to the occurrence of
atrial fibrillation (AF) in humans, but the mechanisms are poorly understood. Experimental …
atrial fibrillation (AF) in humans, but the mechanisms are poorly understood. Experimental …
Upregulation of K2P3.1 K+ Current Causes Action Potential Shortening in Patients With Chronic Atrial Fibrillation
Background—Antiarrhythmic management of atrial fibrillation (AF) remains a major clinical
challenge. Mechanism-based approaches to AF therapy are sought to increase …
challenge. Mechanism-based approaches to AF therapy are sought to increase …
Connexin gene transfer preserves conduction velocity and prevents atrial fibrillation
Background—Several lines of evidence have suggested that maintenance of atrial
fibrillation (AF) depends on reentrant mechanisms. Maintenance of reentry necessitates a …
fibrillation (AF) depends on reentrant mechanisms. Maintenance of reentry necessitates a …
Integrating genetic, transcriptional, and functional analyses to identify 5 novel genes for atrial fibrillation
Background—Atrial fibrillation (AF) affects> 30 million individuals worldwide and is
associated with an increased risk of stroke, heart failure, and death. AF is highly heritable …
associated with an increased risk of stroke, heart failure, and death. AF is highly heritable …
Epicardial adipose tissue as a mediator of cardiac arrhythmias
KHK Patel, T Hwang, C Se Liebers… - American Journal of …, 2022 - journals.physiology.org
Obesity is associated with higher risks of cardiac arrhythmias. Although this may be partly
explained by concurrent cardiometabolic ill-health, growing evidence suggests that …
explained by concurrent cardiometabolic ill-health, growing evidence suggests that …