Unveiling the Multifaceted Roles of ISG15: From Immunomodulation to Therapeutic Frontiers

E Álvarez, M Falqui, L Sin, JP McGrail, B Perdiguero… - Vaccines, 2024 - mdpi.com
The Interferon Stimulated Gene 15 (ISG15), a unique Ubiquitin-like (Ubl) modifier exclusive
to vertebrates, plays a crucial role in the immune system. Primarily induced by interferon …

Rendezvous with Vaccinia Virus in the Post-smallpox Era: R&D Advances

Y Wang - Viruses, 2023 - mdpi.com
Smallpox was eradicated in less than 200 years after Edward Jenner's practice of cowpox
variolation in 1796. The forty-three years of us living free of smallpox, beginning in 1979 …

ISG15–LFA1 interactions in latent HIV clearance: mechanistic implications in designing antiviral therapies

PS Koka, B Ramdass - Frontiers in Cell and Developmental Biology, 2024 - frontiersin.org
Interferon types-I/II (IFN-αβ/γ) secretions are well-established antiviral host defenses. The
human immunodeficiency virus (HIV) particles are known to prevail following targeted …

[HTML][HTML] B and T Cell Bi-Cistronic Multiepitopic Vaccine Induces Broad Immunogenicity and Provides Protection Against SARS-CoV-2

B Perdiguero, E Álvarez, L Marcos-Villar, L Sin… - Vaccines, 2024 - pmc.ncbi.nlm.nih.gov
Background: The COVID-19 pandemic, caused by SARS-CoV-2, has highlighted the need
for vaccines targeting both neutralizing antibodies (NAbs) and long-lasting cross-reactive T …

An atlas of immune cell transcriptomes in human immunodeficiency virus-infected immunological non-responders identified marker genes that control viral replication

Y Chen, X Li, S Liu, W Ao, J Lin, Z Li, S Wu… - Chinese Medical …, 2023 - mednexus.org
Background: Previous studies have examined the bulk transcriptome of peripheral blood
immune cells in acquired immunodeficiency syndrome patients experiencing immunological …

[PDF][PDF] EXPRESSION OF NRDR DIFFERENT ISOFORMS IN MICE UTERUS.

J Shi, S Li, L Tian, Y Liu, S Liu, J Liu, L Ma… - JAPS: Journal of Animal …, 2024 - thejaps.org.pk
Uterus is an important reproductive organ for embryonic growth and development of
viviparous animals. Its normal function is regulated by complex endocrine system and …