Repeated DNA makes up a large fraction of a typical mammalian genome, and some
repetitive elements are able to move within the genome (transposons and retrotransposons) …

The medaka fish Tol2 element is an autonomous transposon that encodes a fully functional
transposase. The transposase protein can catalyze transposition of a transposon construct …

Transgenesis is an important tool for assessing gene function. In zebrafish, transgenesis has
suffered from three problems: the labor of building complex expression constructs using …

In vivo functional investigation of oncogenes using somatic gene transfer has been
successfully exploited to validate their role in tumorigenesis. For tumour suppressor genes …

Astrocytes are one of the most abundant cell types in the mammalian central nervous
system, and are known to have a wide variety of physiological functions, including …

The current consensus recognizes four main medulloblastoma subgroups (wingless, Sonic
hedgehog, group 3 and group 4). While medulloblastoma subgroups have been …

Transposable elements are DNA segments with the unique ability to move about in the
genome. This inherent feature can be exploited to harness these elements as gene vectors …

In the vertebrate embryo, the neural crest forms transiently in the dorsal neural primordium to
yield migratory cells that will invade nearly all tissues and later, will differentiate into bones …

Astrocytes are one of the most abundant cell types in the mammalian brain. They play
essential roles in synapse formation, maturation, and elimination. However, how astrocytes …

Although the genetic triggers for gonadal sex differentiation vary across species, the cell
biology of gonadal development was long thought to be largely conserved. Here, we present …