Topoisomerase IIα in chromosome instability and personalized cancer therapy
Genome instability is a hallmark of cancer cells. Chromosome instability (CIN), which is often
mutually exclusive from hypermutation genotypes, represents a distinct subtype of genome …
mutually exclusive from hypermutation genotypes, represents a distinct subtype of genome …
Statins in anthracycline-induced cardiotoxicity: Rac and Rho, and the heartbreakers
C Henninger, G Fritz - Cell death & disease, 2018 - nature.com
Cancer patients receiving anthracycline-based chemotherapy are at risk to develop life-
threatening chronic cardiotoxicity with the pathophysiological mechanism of action not fully …
threatening chronic cardiotoxicity with the pathophysiological mechanism of action not fully …
Identification of candidate biomarkers correlated with the pathogenesis and prognosis of non-small cell lung cancer via integrated bioinformatics analysis
M Ni, X Liu, J Wu, D Zhang, J Tian, T Wang, S Liu… - Frontiers in …, 2018 - frontiersin.org
Background and Objective: Non-small cell lung cancer (NSCLC) accounts for 80–85% of all
patients with lung cancer and 5-year relative overall survival (OS) rate is less than 20%, so …
patients with lung cancer and 5-year relative overall survival (OS) rate is less than 20%, so …
Target genes of Topoisomerase IIβ regulate neuronal survival and are defined by their chromatin state
Topoisomerases are essential for DNA replication in dividing cells, but their genomic targets
and function in postmitotic cells remain poorly understood. Here we show that a switch in the …
and function in postmitotic cells remain poorly understood. Here we show that a switch in the …
Investigating the potential anticancer activities of antibiotics as topoisomerase II inhibitors and DNA intercalators: in vitro, molecular docking, molecular dynamics, and …
Abstract Topoisomerase II (TOP-2) is a promising molecular target for cancer therapy.
Numerous antibiotics could interact with biologically relevant macromolecules and provoke …
Numerous antibiotics could interact with biologically relevant macromolecules and provoke …
A comprehensive review on acridone based derivatives as future anti-cancer agents and their structure activity relationships
The development of drug resistance and severe side-effects has reduced the clinical efficacy
of the existing anti-cancer drugs available in the market. Thus, there is always a constant …
of the existing anti-cancer drugs available in the market. Thus, there is always a constant …
Amplification of the TOP2A gene does not predict high levels of topoisomerase II alpha protein in human breast tumor samples
RE Mueller, RK Parkes, I Andrulis… - Genes, Chromosomes …, 2004 - Wiley Online Library
Recent clinical trials have suggested that patients whose breast tumors overexpress HER2
may derive particular benefit from anthracycline‐containing chemotherapy compared to that …
may derive particular benefit from anthracycline‐containing chemotherapy compared to that …
Copper-catalyzed three-component synthesis of aminonaphthoquinone–sulfonylamidine conjugates and in vitro evaluation of their antiproliferative activity
A series of aminonaphthoquinone–sulfonylamidine conjugates were synthesized via a
copper-catalyzed three-component reaction of N-propargyl aminonaphthoquinone, sulfonyl …
copper-catalyzed three-component reaction of N-propargyl aminonaphthoquinone, sulfonyl …
New insights into structural, electronic, reactivity, spectroscopic and pharmacological properties of Bergenin: Experimental, DFT calculations, MD and docking …
RA Costa, JN da Silva, VG Oliveira, LM Anselmo… - Journal of Molecular …, 2021 - Elsevier
Bergenin is a polyphenol found in many medicinal plants that presents numerous activities,
such as antiulcer, anti-inflammatory, antifungal, anticancer, antimicrobial, antidiabetic …
such as antiulcer, anti-inflammatory, antifungal, anticancer, antimicrobial, antidiabetic …
The 17q12-q21 amplicon: Her2 and topoisomerase-IIα and their importance to the biology of solid tumours
Her2 and topoisomerase-IIα (T2A) gene amplification are separate events, although the
latter is more frequently seen in Her2 amplified (34–90%) than in Her2 non-amplified (5 …
latter is more frequently seen in Her2 amplified (34–90%) than in Her2 non-amplified (5 …