Understanding and approaching excessive daytime sleepiness

L Pérez-Carbonell, E Mignot, G Leschziner… - The Lancet, 2022 - thelancet.com
Excessive daytime sleepiness (EDS) is a public health issue. However, it remains largely
undervalued, scarcely diagnosed, and poorly supported. Variations in the definition of EDS …

Excessive daytime sleepiness: a clinical review

KD Gandhi, MP Mansukhani, MH Silber… - Mayo Clinic …, 2021 - Elsevier
Excessive daytime sleepiness (EDS) is a highly prevalent condition that is associated with
significant morbidity. The causes of EDS are varied, and include inadequate sleep, sleep …

[HTML][HTML] Diagnosis of central disorders of hypersomnolence: a reappraisal by European experts

GJ Lammers, CLA Bassetti, L Dolenc-Groselj… - Sleep medicine …, 2020 - Elsevier
The aim of this European initiative is to facilitate a structured discussion to improve the next
edition of the International Classification of Sleep Disorders (ICSD), particularly the chapter …

Clinical considerations for the diagnosis of idiopathic hypersomnia

Y Dauvilliers, RK Bogan, I Arnulf, TE Scammell… - Sleep Medicine …, 2022 - Elsevier
Idiopathic hypersomnia is a sleep disorder of neurologic origin characterized by excessive
daytime sleepiness, with sleep inertia, long, unrefreshing naps, and prolonged nighttime …

Narcolepsy

L Barateau, F Pizza, G Plazzi… - Journal of Sleep …, 2022 - Wiley Online Library
This article addresses the clinical presentation, diagnosis, pathophysiology and
management of narcolepsy type 1 and 2, with a focus on recent findings. A low level of …

The orexin story, sleep and sleep disturbances

F Pizza, L Barateau, Y Dauvilliers… - Journal of Sleep …, 2022 - Wiley Online Library
The orexins, also known as hypocretins, are two neuropeptides (orexin A and B or
hypocretin 1 and 2) produced by a few thousand neurons located in the lateral …

Sleepiness in adults: An umbrella review of a complex construct

VP Martin, R Lopez, Y Dauvilliers, JL Rouas… - Sleep medicine …, 2023 - Elsevier
Sleepiness involves many dimensions that require investigation. Since sleepiness is often
defined operationally, we exhaustively inventoried all the assessment tools designed to …

To split or to lump? Classifying the central disorders of hypersomnolence

R Fronczek, I Arnulf, CR Baumann, K Maski, F Pizza… - Sleep, 2020 - academic.oup.com
The classification of the central disorders of hypersomnolence has undergone multiple
iterations in an attempt to capture biologically meaningful disease entities in the absence of …

[HTML][HTML] Idiopathic hypersomnia and other hypersomnia syndromes

LM Trotti, I Arnulf - Neurotherapeutics, 2021 - Elsevier
There are numerous disorders of known or presumed neurologic origin that result in
excessive daytime sleepiness, collectively known as the central disorders of …

Update on the treatment of idiopathic hypersomnia: progress, challenges, and expert opinion

I Arnulf, R Thomas, A Roy, Y Dauvilliers - Sleep Medicine Reviews, 2023 - Elsevier
Idiopathic hypersomnia is a central hypersomnolence disorder of unknown origin
characterized by excessive daytime sleepiness despite normal or long sleep time, and …