[HTML][HTML] Genetics of the human Y chromosome and its association with male infertility

S Colaco, D Modi - Reproductive biology and endocrinology, 2018 - Springer
The human Y chromosome harbors genes that are responsible for testis development and
also for initiation and maintenance of spermatogenesis in adulthood. The long arm of the Y …

[HTML][HTML] Alternative splicing: the pledge, the turn, and the prestige: the key role of alternative splicing in human biological systems

LM Gallego-Paez, MC Bordone, AC Leote… - Human genetics, 2017 - Springer
Alternative pre-mRNA splicing is a tightly controlled process conducted by the spliceosome,
with the assistance of several regulators, resulting in the expression of different transcript …

[HTML][HTML] Deciphering highly similar multigene family transcripts from Iso-Seq data with IsoCon

K Sahlin, M Tomaszkiewicz, KD Makova… - Nature …, 2018 - nature.com
A significant portion of genes in vertebrate genomes belongs to multigene families, with
each family containing several gene copies whose presence/absence, as well as isoform …

Human embryonic stem cell-derived cardiovascular progenitor cells efficiently colonize in bFGF-tethered natural matrix to construct contracting humanized rat hearts

S Rajabi, S Pahlavan, MK Ashtiani, H Ansari… - Biomaterials, 2018 - Elsevier
Bioengineering of whole hearts using human embryonic stem cells (hESCs)-derived
cardiovascular progenitor cells (CPCs) and natural matrices is a promising approach to …

Y chromosome missing protein, TBL1Y, may play an important role in cardiac differentiation

A Meyfour, H Ansari, S Pahlavan… - Journal of proteome …, 2017 - ACS Publications
Despite evidence for sex-specific cardiovascular physiology and pathophysiology, the
biological basis for this dimorphism remains to be explored. Apart from hormonal factors …

[HTML][HTML] KDM5 family as therapeutic targets in breast cancer: Pathogenesis and therapeutic opportunities and challenges

CY Li, W Wang, CH Leung, GJ Yang, J Chen - Molecular Cancer, 2024 - Springer
Breast cancer (BC) is the most frequent malignant cancer diagnosis and is a primary factor
for cancer deaths in women. The clinical subtypes of BC include estrogen receptor (ER) …

[HTML][HTML] Emerging of lysine demethylases (KDMs): From pathophysiological insights to novel therapeutic opportunities

S Arifuzzaman, MR Khatun, R Khatun - Biomedicine & Pharmacotherapy, 2020 - Elsevier
In recent years, there have been remarkable scientific advancements in the understanding
of lysine demethylases (KDMs) because of their demethylation of diverse substrates …

[HTML][HTML] Studies on the interaction of the histone demethylase KDM5B with tricarboxylic acid cycle intermediates

H Tarhonskaya, RP Nowak, C Johansson… - Journal of Molecular …, 2017 - Elsevier
Methylation of lysine-4 of histone H3 (H3K4me n) is an important regulatory factor in
eukaryotic transcription. Removal of the transcriptionally activating H3K4 methylation is …

[HTML][HTML] Domestication explains two-thirds of differential-gene-expression variance between domestic and wild animals; the remaining one-third reflects intraspecific …

I Chadaeva, P Ponomarenko, R Kozhemyakina… - Animals, 2021 - mdpi.com
Simple Summary Before genomes were sequenced, zoologists had discovered destabilizing
selection as a general pattern of animal domestication that in foxes and minks had yielded …

The expression of Cysteine-Rich Secretory Protein 2 (CRISP2) and miR-582-5p in seminal plasma fluid and spermatozoa of infertile men

D Gholami, RS Yazdi, MS Jami, S Ghasemi… - Gene, 2020 - Elsevier
Abstract Cysteine-Rich Secretory Protein 2 (CRISP2) plays an important role in the
morphology and motion of male ejaculated spermatozoa. The association of its expression …