Metastasis is responsible for the greatest number of cancer deaths. Metastatic disease, or
the movement of cancer cells from one site to another, is a complex process requiring …

Metastasis can be viewed as an evolutionary process, culminating in the prevalence of rare
tumour cells that overcame stringent physiological barriers as they separated from their …

The variability in the prognosis of individuals with hepatocellular carcinoma (HCC) suggests
that HCC may comprise several distinct biological phenotypes. These phenotypes may …

Metastatic cancers, once established, are the primary cause of mortality associated with
cancer. Previously, we used a genomic approach to identify metastasis-associated genes in …

The movement of cancer cells into tissue surrounding the tumour and the vasculature is the
first step in the spread of metastatic cancers. Recent advances in imaging, the use of 3D …

Metastasis, the spread of a tumor from its primary site to other parts of the body, continues to
be the most significant problem in the field of cancer. Patients who present with metastatic …

The Notch family of proteins plays an integral role in determining cell fates, such as
proliferation, differentiation, and apoptosis. We show that Notch-1 and its ligands, Delta-like …

Members of the ezrin–radixin–moesin (ERM) family of proteins are involved in multiple
aspects of cell migration by acting both as crosslinkers between the membrane, receptors …

Rhabdomyosarcoma (RMS) is a childhood cancer originating from skeletal muscle, and
patient survival is poor in the presence of metastatic disease. Few determinants that regulate …

Purpose: We aimed to find key molecules associated with chemoresistance in ovarian
cancer using gene expression profiling as a screening tool. Experimental Design: Using two …