Epithelial barrier hypothesis: effect of the external exposome on the microbiome and epithelial barriers in allergic disease

Z Celebi Sozener, B Ozdel Ozturk, P Cerci, M Turk… - Allergy, 2022 - Wiley Online Library
Environmental exposure plays a major role in the development of allergic diseases. The
exposome can be classified into internal (eg, aging, hormones, and metabolic processes) …

A comprehensive understanding of ambient particulate matter and its components on the adverse health effects based from epidemiological and laboratory evidence

T Li, Y Yu, Z Sun, J Duan - Particle and fibre toxicology, 2022 - Springer
The impacts of air pollution on public health have become a great concern worldwide.
Ambient particulate matter (PM) is a major air pollution that comprises a heterogeneous …

Allergy: Mechanistic insights into new methods of prevention and therapy

CA Akdis, M Akdis, SD Boyd, V Sampath… - Science Translational …, 2023 - science.org
In the past few decades, the prevalence of allergic diseases has increased worldwide. Here,
we review the etiology and pathophysiology of allergic diseases, including the role of the …

The external exposome and allergies: from the perspective of the epithelial barrier hypothesis

Z Celebi Sozener, Ü Özbey Yücel, S Altiner… - Frontiers in …, 2022 - frontiersin.org
Introduction In the last decades, we have seen a rapid increase in the prevalence of allergic
diseases such as asthma, allergic rhinitis, atopic dermatitis, and food allergies. The …

Gene‐environment interactions in childhood asthma revisited; expanding the interaction concept

N Hernandez‐Pacheco, M Kere… - Pediatric Allergy and …, 2022 - Wiley Online Library
Investigation of gene‐environment interactions (GxE) may provide important insights into the
gene regulatory framework in response to environmental factors of relevance for childhood …

Air pollution exposure is linked with methylation of immunoregulatory genes, altered immune cell profiles, and increased blood pressure in children

M Prunicki, N Cauwenberghs, J Lee, X Zhou… - Scientific reports, 2021 - nature.com
Ambient air pollution exposure is associated with cardiovascular dysregulation and immune
system alterations, yet no study has investigated both simultaneously in children …

Particulate matter exposure shapes DNA methylation through the lifespan

L Ferrari, M Carugno, V Bollati - Clinical epigenetics, 2019 - Springer
Exposure to airborne particulate matter (PM) has been associated with detrimental health
effects. DNA methylation represents the most well-studied epigenetic factor among the …

Cumulative lifetime burden of cardiovascular disease from early exposure to air pollution

JB Kim, M Prunicki, F Haddad, C Dant… - Journal of the …, 2020 - Am Heart Assoc
The disease burden associated with air pollution continues to grow. The World Health
Organization (WHO) estimates≈ 7 million people worldwide die yearly from exposure to …

A nationwide study of air pollution from particulate matter and daily hospitalizations for respiratory diseases in Italy

M Renzi, M Scortichini, F Forastiere… - Science of the Total …, 2022 - Elsevier
Background/aim The relationship between air pollution and respiratory morbidity has been
widely addressed in urban and metropolitan areas but little is known about the effects in non …

An evaluation of supervised methods for identifying differentially methylated regions in Illumina methylation arrays

S Mallik, GJ Odom, Z Gao, L Gomez… - Briefings in …, 2019 - academic.oup.com
Epigenome-wide association studies (EWASs) have become increasingly popular for
studying DNA methylation (DNAm) variations in complex diseases. The Illumina methylation …