Invasive candidiasis (IC) is a serious infection caused by several Candida species, and the
most common fungal disease in hospitals in high-income countries. Despite overall …

Invasive candidiasis (IC), due to the yeast pathogen Candida, is still a major cause of in-
hospital morbidity and mortality. The limited number of antifungal drug classes and the …

Abstract Treatment of invasive fungal infections (IFIs) remains challenging, because of the
limitations of the current antifungal agents (ie, mode of administration, toxicity, and drug-drug …

Introduction The epidemiology of invasive Candida infections is evolving. Infections caused
by non-albicans Candida spp. are increasing; however, the antifungal pipeline is more …

In many ways, fungal diseases are forgotten or neglected. Given the significantly lower
frequency compared to similar bacterial etiologies across the spectrum of infectious …

Mucosal and invasive candidiasis can be challenging to treat in the setting of drug
intolerance, antifungal resistance, drug–drug interactions, or host immune status …

Introduction Over the last two decades, we have experienced pressing needs for new
additions to the antifungal armamentarium given the emergence of resistant fungi, the …

Abstract Objectives Fosmanogepix (APX001), a first-in-class, intravenous (IV) and oral (PO)
antifungal prodrug, is being developed to treat invasive fungal diseases (IFDs). Manogepix …

Fungal infections are a major public health problem resulting from the lack of public policies
addressing these diseases, toxic and/or expensive therapeutic tools, scarce diagnostic tests …

Citrullus lanatus seed is an important but neglected seed rich in essential fatty acids. The
study sought to investigate in silico and in vivo antifungal activity of some bioactive …