F Lamoth - Infection and Drug Resistance, 2023 - Taylor & Francis
Invasive candidiasis (IC), due to the yeast pathogen Candida, is still a major cause of in- hospital morbidity and mortality. The limited number of antifungal drug classes and the …
F Lamoth, RE Lewis… - Clinical Infectious …, 2022 - academic.oup.com
Abstract Treatment of invasive fungal infections (IFIs) remains challenging, because of the limitations of the current antifungal agents (ie, mode of administration, toxicity, and drug-drug …
Introduction The epidemiology of invasive Candida infections is evolving. Infections caused by non-albicans Candida spp. are increasing; however, the antifungal pipeline is more …
TP McCarty, PG Pappas - Frontiers in cellular and infection …, 2021 - frontiersin.org
In many ways, fungal diseases are forgotten or neglected. Given the significantly lower frequency compared to similar bacterial etiologies across the spectrum of infectious …
Mucosal and invasive candidiasis can be challenging to treat in the setting of drug intolerance, antifungal resistance, drug–drug interactions, or host immune status …
CF Neoh, W Jeong, DCM Kong… - Expert Review of Anti …, 2023 - Taylor & Francis
Introduction Over the last two decades, we have experienced pressing needs for new additions to the antifungal armamentarium given the emergence of resistant fungi, the …
Abstract Objectives Fosmanogepix (APX001), a first-in-class, intravenous (IV) and oral (PO) antifungal prodrug, is being developed to treat invasive fungal diseases (IFDs). Manogepix …
HC de Oliveira, BT Bezerra… - ACS bio & med Chem …, 2022 - ACS Publications
Fungal infections are a major public health problem resulting from the lack of public policies addressing these diseases, toxic and/or expensive therapeutic tools, scarce diagnostic tests …
Citrullus lanatus seed is an important but neglected seed rich in essential fatty acids. The study sought to investigate in silico and in vivo antifungal activity of some bioactive …