'The development of a multicellular organism from a single egg cell requires both the
determination of many cell types and the organization of these cells into an elaborate pattern …

The metameric organization of the Drosophila embryo is generated in the first 5 h after
fertilization. An initially rather simple pattern provides the foundation for subsequent …

The zinc finger DNA-binding motif occurs in many proteins that regulate eukaryotic gene
expression. The crystal structure of a complex containing the three zinc fingers from Zif268 …

The bicoid (bcd) protein in a Drosophila embryo is derived from an anteriorly localized
mRNA and comes to be distributed in an exponential concentration gradient along the …

We have developed a non-radioactive in situ hybridization technique for the localization of
RNA in whole mount Drosophila embryos. After fixation, whole embryos are hybridized in …

The oskar gene directs germ plasm assembly and controls the number of germ cell
precursors formed at the posterior pole of the Drosophila embryo. Mislocalization of oskar …

Transcription factor Spl is a protein present in mammalian cells that binds to GC box
promoter elements and selectively activates mRNA synthesis from genes that contain …

Early embryonic patterning events are strikingly precise, a fact that appears incompatible
with the stochastic gene expression observed across phyla. Using single-molecule mRNA …

The or/A gene of A. nidulans mediates the developmental switch from the indeterminate,
apical growth pattern of vegetative cells to the budding growth pattern of conidiophores. br/A …

In a screen for transcriptional regulators that control differentiation into the T cell lineage, a
complementary DNA was isolated encoding a zinc finger protein (Ikaros) related to the …