Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications
SW Ryter, J Alam, AMK Choi - Physiological reviews, 2006 - journals.physiology.org
The heme oxygenases, which consist of constitutive and inducible isozymes (HO-1, HO-2),
catalyze the rate-limiting step in the metabolic conversion of heme to the bile pigments (ie …
catalyze the rate-limiting step in the metabolic conversion of heme to the bile pigments (ie …
JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
The ultraviolet (UV) reaponee of mammalian cells is charactarlxed by a rapid and eelectlve
Increaee In gene expreeelon medlated by AP-1 and NF-KB. The effect on AP-1 …
Increaee In gene expreeelon medlated by AP-1 and NF-KB. The effect on AP-1 …
The heme synthesis and degradation pathways: role in oxidant sensitivity: heme oxygenase has both pro-and antioxidant properties
SW Ryter, RM Tyrrell - Free Radical Biology and Medicine, 2000 - Elsevier
The heme biosynthetic and catabolic pathways generate pro-and antioxidant compounds,
and consequently, influence cellular sensitivity to oxidants. Heme precursors (δ …
and consequently, influence cellular sensitivity to oxidants. Heme precursors (δ …
Oxidant and antioxidant balance in the airways and airway diseases
I Rahman, SK Biswas, A Kode - European journal of pharmacology, 2006 - Elsevier
Although oxygen is a prerequisite to life, at concentrations beyond the physiological limits it
may be hazardous to the cells. Since the lungs are directly exposed to very high amounts of …
may be hazardous to the cells. Since the lungs are directly exposed to very high amounts of …
Heme oxygenase: colors of defense against cellular stress
LE Otterbein, AMK Choi - American Journal of Physiology …, 2000 - journals.physiology.org
The discovery of the gaseous molecule nitric oxide in 1987 unraveled investigations on its
functional role in the pathogenesis of a wide spectrum of biological and pathological …
functional role in the pathogenesis of a wide spectrum of biological and pathological …
Heme oxygenase/carbon monoxide signaling path-ways: Regulation and functional significance
SW Ryter, LE Otterbein, D Morse, AMK Choi - Oxygen/Nitrogen Radicals …, 2002 - Springer
Carbon monoxide (CO), a gaseous second messenger, arises in biological systems during
the oxidative catabolism of heme by the heme oxygenase (HO) enzymes. HO exists as …
the oxidative catabolism of heme by the heme oxygenase (HO) enzymes. HO exists as …
Heme oxygenase-1: the “emerging molecule” has arrived
D Morse, AMK Choi - American journal of respiratory cell and …, 2002 - atsjournals.org
Organisms on our planet have evolved in an oxidizing environment that is intrinsically
inimical to life, and cells have been forced to devise means of protecting themselves. One of …
inimical to life, and cells have been forced to devise means of protecting themselves. One of …
Hepatic ischemia/reperfusion injury—a fresh look
C Fondevila, RW Busuttil… - … and molecular pathology, 2003 - Elsevier
Ischemia/reperfusion (I/R) injury is a multifactorial process that affects graft function after liver
transplantation. An understanding of the mechanisms involved in I/R injury is essential for …
transplantation. An understanding of the mechanisms involved in I/R injury is essential for …
Regulation of redox glutathione levels and gene transcription in lung inflammation: therapeutic approaches
I Rahman, W MacNee - Free Radical Biology and Medicine, 2000 - Elsevier
Glutathione (l-γ-glutamyl-l-cysteinylglycine, GSH), is a vital intra-and extracellular protective
antioxidant. Glutathione is synthesized from its constituent amino acids by the sequential …
antioxidant. Glutathione is synthesized from its constituent amino acids by the sequential …