Apoptosis, a form of programmed cell death, is responsible for eliminating damaged or
unnecessary cells in multicellular organisms. Various types of intracellular stress trigger …

Recent years have witnessed a flurry of important technological and methodological
developments in the discovery and analysis of copy number variations (CNVs), which are …

The kidney has tremendous capacity to repair after acute injury, however, pathways guiding
adaptive and fibrotic repair are poorly understood. We developed a model of adaptive and …

The identification of small molecules that target specific CFTR variants has ushered in a new
era of treatment for cystic fibrosis (CF), yet optimal, individualized treatment of CF will require …

Metabolic dysregulation promotes cancer growth through not only energy production, but
also epigenetic reprogramming. Here, we report that a critical node in methyl donor …

In many respects, genetic studies in cystic fibrosis (CF) serve as a paradigm for a human
Mendelian genetic success story. From recognition of the condition as a heritable …

Background Improved understanding of the pathways associated with airway
pathophysiologic features in COPD will identify new predictive biomarkers and novel …

While the metabolic changes in cancer tissues were first observed by Warburg Otto almost a
century ago, altered metabolism has recently returned as a focus of cancer research. 5' …

Coxiella burnetii replicates in an acidified lysosome-derived vacuole. Biogenesis of the
Coxiella-containing vacuole (CCV) requires bacterial effector proteins delivered into host …

Pathogens have been a strong driving force for natural selection. Therefore, understanding
how human genetic differences impact infection-related cellular traits can mechanistically …