Owing to their inherent three-dimensionality and structural novelty, spiro scaffolds have
been increasingly utilized in drug discovery. In this brief review, we highlight selected …

Computational methods are well-established tools in the drug discovery process and can be
employed for a variety of tasks. Common applications include lead identification and scaffold …

Glucocorticoids are steroid hormones with potent immunosuppressive properties. Their
primary source is the adrenals, where they are generated via de novo synthesis from …

Aminoarylbenzosuberene (AAB) molecules were chosen for in silico analysis to develop
effective and more competent 11β-hydroxysteroid dehydrogenase (11β-HSD1) protein …

Conspectus “Total synthesis endeavors provide wonderful opportunities to discover and
invent new synthetic reactions as a means to advance organic synthesis in general. Such …

beta‐hydroxysteroid dehydrogenases (11β‐HSDs) catalyse the conversion of active 11‐
hydroxy glucocorticoids (cortisol, corticosterone) and their inert 11‐keto forms (cortisone, 11 …

Background Immune responses against tumors are subject to negative feedback regulation.
Immune checkpoint inhibitors (ICIs) blocking Programmed cell death protein 1 (PD-1), a …

Apoptosis and autophagy are involved in neural development and in the response of the
nervous system to a variety of insults. Apoptosis is responsible for cell elimination, whereas …

In this study we developed a method for the pyridine-directed, rhodium-catalyzed, site-
selective C–H alkylation and arylation of pyridones using commercially available …

Cortisol, commonly known as the" stress hormone," plays a critical role in the body's
response to stress. Elevated cortisol levels have been associated with various mental …