Cisplatin (CDDP) is the drug of choice against different types of cancer. However, tumor
cells can acquire resistance to the damage caused by cisplatin, generating genetic and …

Breast cancer is one of the leading causes of mortality among women worldwide due to
aggressive behavior, early metastasis, resistance to existing chemotherapeutic agent and …

Docetaxel is a chemotherapy drug to treat breast cancer, however as with many
chemotherapeutic drugs resistance to docetaxel occurs in 50% of patients, and the …

Purpose: Doxorubicin is administrated as a single agent in first-line therapy of breast cancer
to induce apoptosis in tumor cells. Bax, Bcl-xL, Caspase-8 and 9 proteins are involved in …

The combination of a chemotherapeutic drug with a P-glycoprotein (P-gp) inhibitor has
emerged as a promising strategy for treating multidrug resistance (MDR) cancer. To ensure …

High matrix metalloproteinase 1 (MMP1) expression is associated with enhanced breast
cancer growth and metastasis and also might predict poor prognosis. In this study, we further …

Breast cancer treatment is hampered by drug resistance which leads to recurrence and
metastasis. Alteration of specific gene expression such as ERCC1 evidently acquires drug …

Breast cancer is one of the most life threatening risks in women's life. In spite of considerable
progress in its understanding and challenges, treatment is not yet the correct word to apply …

Industrialisation, the proximity of factories to cities, and human work activities have led to a
disproportionate use of substances containing heavy metals, such as cadmium (Cd), which …

The reaction of bis-sulfone conjugation reagents with disulfide bonds allows the site-specific
modification of various peptides and proteins. Herein, we present the intracellular …