Intraflagellar transport (IFT) is a form of motor‐dependent cargo transport that is essential for
the assembly, maintenance, and length control of cilia, which play critical roles in motility …

A molecular motor is made of either a single macromolecule or a macromolecular complex.
Just like their macroscopic counterparts, molecular motors “transduce” input energy into …

Long-distance transport in eukaryotic cells is driven by molecular motors that move along
microtubule tracks. Molecular motors of the kinesin superfamily contain a kinesin motor …

Intracellular transport depends on cooperation between distinct motor proteins. Two
anterograde intraflagellar transport (IFT) motors, heterotrimeric kinesin-II and homodimeric …

Intraflagellar transport (IFT) sculpts the proteome of cilia and flagella; the antenna-like
organelles found on the surface of virtually all human cell types. By delivering proteins to the …

Kinesin-2 was first purified as a heterotrimeric, anterograde, microtubule-based motor
consisting of two distinct kinesin-related subunits and a novel associated protein (KAP) that …

Cilia are eukaryotic organelles essential for movement, signaling or sensing. Primary cilia
act as antennae to sense a cell's environment and are involved in a wide range of signaling …

Cilia are multifunctional organelles that are constructed using intraflagellar transport (IFT) of
cargo to and from their tip. It is widely held that the retrograde IFT motor, dynein-2, must be …

The response of motor proteins to external loads underlies their ability to work in teams and
determines the net speed and directionality of cargo transport. The mammalian kinesin-2 …

Intraflagellar transport (IFT) orchestrates entry of proteins into primary cilia. At the ciliary
base, assembled IFT trains, driven by kinesin-2 motors, can transport cargo proteins into the …