Blood flow forces in shaping the vascular system: a focus on endothelial cell behavior
The endothelium is the cell monolayer that lines the interior of the blood vessels separating
the vessel lumen where blood circulates, from the surrounding tissues. During embryonic …
the vessel lumen where blood circulates, from the surrounding tissues. During embryonic …
High wall shear stress and spatial gradients in vascular pathology: a review
Cardiovascular pathologies such as intracranial aneurysms (IAs) and atherosclerosis
preferentially localize to bifurcations and curvatures where hemodynamics are complex …
preferentially localize to bifurcations and curvatures where hemodynamics are complex …
Endothelial cell sensing of flow direction
Objective—Atherosclerosis-prone regions of arteries are characterized by complex flow
patterns where the magnitude of shear stress is low and direction rapidly changes, termed …
patterns where the magnitude of shear stress is low and direction rapidly changes, termed …
A computational study of red blood cell deformability effect on hemodynamic alteration in capillary vessel networks
S Ebrahimi, P Bagchi - Scientific reports, 2022 - nature.com
Capillary blood vessels, the smallest vessels in the body, form an intricate network with
constantly bifurcating, merging and winding vessels. Red blood cells (RBCs) must navigate …
constantly bifurcating, merging and winding vessels. Red blood cells (RBCs) must navigate …
Hemodynamic stress, inflammation, and intracranial aneurysm development and rupture: a systematic review
F Signorelli, S Sela, L Gesualdo, S Chevrel, F Tollet… - World neurosurgery, 2018 - Elsevier
Background There seems to be a pathogenetic link between hemodynamics and
inflammatory arterial wall alteration leading to the development and rupture of intracranial …
inflammatory arterial wall alteration leading to the development and rupture of intracranial …
CFD: computational fluid dynamics or confounding factor dissemination? The role of hemodynamics in intracranial aneurysm rupture risk assessment
Image-based computational fluid dynamics holds a prominent position in the evaluation of
intracranial aneurysms, especially as a promising tool to stratify rupture risk. Current …
intracranial aneurysms, especially as a promising tool to stratify rupture risk. Current …
High spatial endothelial shear stress gradient independently predicts site of acute coronary plaque rupture and erosion
V Thondapu, C Mamon, EKW Poon… - Cardiovascular …, 2021 - academic.oup.com
Aims To investigate local haemodynamics in the setting of acute coronary plaque rupture
and erosion. Methods and results Intracoronary optical coherence tomography performed in …
and erosion. Methods and results Intracoronary optical coherence tomography performed in …
High fluid shear stress and spatial shear stress gradients affect endothelial proliferation, survival, and alignment
Cerebral aneurysms develop near bifurcation apices, where complex hemodynamics occur:
Flow impinges on the apex, accelerates into branches, then slows again distally, creating …
Flow impinges on the apex, accelerates into branches, then slows again distally, creating …
Inflammation and cerebral aneurysms
Cerebral aneurysms (CAs) occur in up to 5% of the population in the US, and up to 7% of all
strokes are caused by CA rupture. Little is known about the pathophysiology of cerebral …
strokes are caused by CA rupture. Little is known about the pathophysiology of cerebral …
Microvascular endothelial cells migrate upstream and align against the shear stress field created by impinging flow
At present, little is known about how endothelial cells respond to spatial variations in fluid
shear stress such as those that occur locally during embryonic development, at heart valve …
shear stress such as those that occur locally during embryonic development, at heart valve …