Selective leptin resistance revisited
AL Mark - … Journal of Physiology-Regulatory, Integrative and …, 2013 - journals.physiology.org
In addition to effects on appetite and metabolism, leptin influences many neuroendocrine
and physiological systems, including the sympathetic nervous system. Building on my Carl …
and physiological systems, including the sympathetic nervous system. Building on my Carl …
[HTML][HTML] Leptin resensitisation: a reversion of leptin-resistant states
Leptin resistance refers to states in which leptin fails to promote its anticipated effects,
frequently coexisting with hyperleptinaemia. Leptin resistance is closely associated with …
frequently coexisting with hyperleptinaemia. Leptin resistance is closely associated with …
[HTML][HTML] Distinct hypothalamic neurons mediate estrogenic effects on energy homeostasis and reproduction
Y Xu, TP Nedungadi, L Zhu, N Sobhani, BG Irani… - Cell metabolism, 2011 - cell.com
Estrogens regulate body weight and reproduction primarily through actions on estrogen
receptor-α (ERα). However, ERα-expressing cells mediating these effects are not identified …
receptor-α (ERα). However, ERα-expressing cells mediating these effects are not identified …
[HTML][HTML] p70S6 kinase phosphorylates AMPK on serine 491 to mediate leptin's effect on food intake
Summary The PI3K-AKT, mTOR-p70S6 kinase and AMPK pathways play distinct and critical
roles in metabolic regulation. Each pathway is necessary for leptin's anorexigenic effects in …
roles in metabolic regulation. Each pathway is necessary for leptin's anorexigenic effects in …
[HTML][HTML] Fetal radiofrequency radiation exposure from 800-1900 mhz-rated cellular telephones affects neurodevelopment and behavior in mice
Neurobehavioral disorders are increasingly prevalent in children, however their etiology is
not well understood. An association between prenatal cellular telephone use and …
not well understood. An association between prenatal cellular telephone use and …
High-fat feeding promotes obesity via insulin receptor/PI3K-dependent inhibition of SF-1 VMH neurons
T Klöckener, S Hess, BF Belgardt, L Paeger… - Nature …, 2011 - nature.com
Abstract Steroidogenic factor 1 (SF-1)-expressing neurons of the ventromedial
hypothalamus (VMH) control energy homeostasis, but the role of insulin action in these cells …
hypothalamus (VMH) control energy homeostasis, but the role of insulin action in these cells …
Ventromedial hypothalamic OGT drives adipose tissue lipolysis and curbs obesity
The ventromedial hypothalamus (VMH) is known to regulate body weight and
counterregulatory response. However, how VMH neurons regulate lipid metabolism and …
counterregulatory response. However, how VMH neurons regulate lipid metabolism and …
Steroidogenic factor 1 directs programs regulating diet-induced thermogenesis and leptin action in the ventral medial hypothalamic nucleus
KW Kim, L Zhao, J Donato Jr… - Proceedings of the …, 2011 - National Acad Sciences
The transcription factor steroidogenic factor 1 (SF-1) is exclusively expressed in the brain in
the ventral medial hypothalamic nucleus (VMH) and is required for the development of this …
the ventral medial hypothalamic nucleus (VMH) and is required for the development of this …
[HTML][HTML] SIRT1 deacetylase in SF1 neurons protects against metabolic imbalance
G Ramadori, T Fujikawa, J Anderson, ED Berglund… - Cell metabolism, 2011 - cell.com
Chronic feeding on high-calorie diets causes obesity and type 2 diabetes mellitus (T2DM),
illnesses that affect hundreds of millions. Thus, understanding the pathways protecting …
illnesses that affect hundreds of millions. Thus, understanding the pathways protecting …
[HTML][HTML] Activation of serotonin 2C receptors in dopamine neurons inhibits binge-like eating in mice
Background Neural networks that regulate binge eating remain to be identified, and effective
treatments for binge eating are limited. Methods We combined neuroanatomic …
treatments for binge eating are limited. Methods We combined neuroanatomic …