Complex biological systems and cellular networks may underlie most genotype to
phenotype relationships. Here, we review basic concepts in network biology, discussing …

Rapid technological advances have led to the production of different types of biological data
and enabled construction of complex networks with various types of interactions between …

Abstract Background Psoriasis impacts 1–3% of the world's population and is characterized
by hyper-proliferation of keratinocytes and increased inflammation. At the molecular level …

RNA granules have been likened to liquid droplets whose dynamics depend on the
controlled dissolution and condensation of internal components. The molecules and …

We systematically generated large-scale data sets to improve genome annotation for the
nematode Caenorhabditis elegans, a key model organism. These data sets include …

Studying protein interaction networks of all proteins in an organism (“interactomes”) remains
one of the major challenges in modern biomedicine. Such information is crucial to …

Plants have unique features that evolved in response to their environments and ecosystems.
A full account of the complex cellular networks that underlie plant-specific functions is still …

Current epigenomics approaches have facilitated the genome-wide identification of
regulatory elements based on chromatin features and transcriptional regulator binding and …

Today, it is widely appreciated that protein–protein interactions play a fundamental role in
biological processes. This was not always the case. The study of protein interactions started …

Over the past decade, bimolecular fluorescence complementation (BiFC) has emerged as a
key technique to visualize protein-protein interactions in a variety of model organisms. The …