Iron and manganese-related CNS toxicity: mechanisms, diagnosis and treatment
P Chen, M Totten, Z Zhang, H Bucinca… - Expert review of …, 2019 - Taylor & Francis
ABSTRACT Introduction: Iron (Fe) and manganese (Mn) are essential nutrients for humans.
They act as cofactors for a variety of enzymes. In the central nervous system (CNS), these …
They act as cofactors for a variety of enzymes. In the central nervous system (CNS), these …
Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein
The aggregation of α-synuclein (αSyn) is considered a key pathophysiological feature of
certain neurodegenerative disorders, collectively termed synucleinopathies. Given that a …
certain neurodegenerative disorders, collectively termed synucleinopathies. Given that a …
Manganese activates NLRP3 inflammasome signaling and propagates exosomal release of ASC in microglial cells
Chronic, sustained inflammation underlies many pathological conditions, including
neurodegenerative diseases. Divalent manganese (Mn2+) exposure can stimulate …
neurodegenerative diseases. Divalent manganese (Mn2+) exposure can stimulate …
Manganese exposure and neurologic outcomes in adult populations
KV Martin, D Edmondson, KM Cecil… - Neurologic …, 2020 - neurologic.theclinics.com
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The schizophrenia risk locus in SLC39A8 alters brain metal transport and plasma glycosylation
A common missense variant in SLC39A8 is convincingly associated with schizophrenia and
several additional phenotypes. Homozygous loss-of-function mutations in SLC39A8 result in …
several additional phenotypes. Homozygous loss-of-function mutations in SLC39A8 result in …
Thalamic GABA levels and occupational manganese neurotoxicity: Association with exposure levels and brain MRI
Excessive occupational exposure to Manganese (Mn) has been associated with clinical
symptoms resembling idiopathic Parkinson's disease (IPD), impairing cognitive and motor …
symptoms resembling idiopathic Parkinson's disease (IPD), impairing cognitive and motor …
[HTML][HTML] Whole-brain mapping of increased manganese levels in welders and its association with exposure and motor function
Although manganese (Mn) is a trace metal essential for humans, chronic exposure to Mn
can cause accumulation of this metal ion in the brain leading to an increased risk of …
can cause accumulation of this metal ion in the brain leading to an increased risk of …
Synergy as a new and sensitive marker of basal ganglia dysfunction: A study of asymptomatic welders
Background Multi-digit synergies, a recently developed, theory-based method to quantify
stability of motor action, are shown to reflect basal ganglia dysfunction associated with …
stability of motor action, are shown to reflect basal ganglia dysfunction associated with …
MRI signal intensity and parkinsonism in manganese-exposed workers
SR Criswell, SS Nielsen, MN Warden… - … of occupational and …, 2019 - journals.lww.com
Objective: T1-weighted brain magnetic resonance imaging (MRI) of the basal ganglia
provides a noninvasive measure of manganese (Mn) exposure, and may also represent a …
provides a noninvasive measure of manganese (Mn) exposure, and may also represent a …
Derivation of an occupational exposure level for manganese in welding fumes
LA Bailey, LE Kerper, JE Goodman - Neurotoxicology, 2018 - Elsevier
Exposure to high levels of manganese (Mn) in occupational settings is known to lead to
adverse neurological effects. Since Mn is an essential nutrient, there are mechanisms that …
adverse neurological effects. Since Mn is an essential nutrient, there are mechanisms that …