Ever present hurdles for the discovery of new drugs for cancer therapy have necessitated
the development of the alternative strategy of drug repurposing, the development of old …

Neuroinflammation is initiated when glial cells, mainly microglia, are activated by threats to
the neural environment, such as pathogen infiltration or neuronal injury. Although …

A number of human teratogens elicit their deleterious effects through mechanisms involving
the generation of reactive oxygen species (ROS) and oxidative stress. However, classic …

In 1956,(±)-thalidomide was introduced into the market in Europe as sedative and drug for
morning sleeping sickness which resulted into a tragedy called thalidomide tragedy …

From the last two decades, phthalimide analogues received prime interest from scientists
due to its potent inhibitory action on different cancer‐causing receptors. A variety of …

Tumor necrosis factor alpha (TNF-α) is a pleiotropic inflammatory cytokine. The cytokine
possesses both growth stimulating properties and growth inhibitory processes, and it …

A new and convenient synthesis for amino‐phthalimide (1H‐isoindole‐1, 3 (2H)‐dione)
derivatives has been developed starting from an α, β‐unsaturated ketone. The ketones were …

Summary Five (1a-5e) isoindoline-1, 3-dione derivatives were synthesized and
characterized by IR, 1 H NMR, and Mass spectroscopy. They were evaluated for in vivo …

A series of N-phenyl thalidomide analogues have been prepared efficiently through a
Buchwald–Hartwig cross coupling reaction as the key step. Several of these compounds …

Aims We studied the effect of thalidomide on NFκB-induced TNF-α in acute pancreatitis-
associated lung injury in the rat. Methods Rats were intragastrically administered …