Epilepsy is a chronic neurologic disorder that affects over 70 million people worldwide.
Despite the availability of over 20 antiseizure drugs (ASDs) for symptomatic treatment of …

Coffee is one of the most widely consumed beverages worldwide. It is usually identified as a
stimulant because of a high content of caffeine. However, caffeine is not the only coffee …

The brain must dynamically integrate, coordinate, and respond to internal and external
stimuli across multiple time scales. Non-invasive measurements of brain activity with fMRI …

Abstract gamma-Aminobutyric acid (GABA)-mediated inhibitory neurotransmission and the
gene products involved were discovered during the mid-twentieth century. Historically …

Epilepsy is a chronic neurological condition characterized by recurrent seizures that affects
millions of people worldwide. Comprehension of the complex mechanisms underlying …

Epileptogenesis is a chronic process that can be triggered by genetic or acquired factors,
and that can continue long after epilepsy diagnosis. In 2015, epileptogenesis is not a …

Temporal lobe epilepsy causes severe cognitive deficits, but the circuit mechanisms remain
unknown. Interneuron death and reorganization during epileptogenesis may disrupt the …

Epilepsy has been historically seen as a functional brain disorder associated with excessive
synchronization of large neuronal populations leading to a hypersynchronous state. Recent …

Antiepileptic drugs (AEDs) have many benefits but also many side effects, including
aggression, agitation, and irritability, in some patients with epilepsy. This article offers a …

Mossy cells comprise a large fraction of the cells in the hippocampal dentate gyrus,
suggesting that their function in this region is important. They are vulnerable to ischaemia …