Cyclic peptides are fascinating molecules abundantly found in nature and exploited as
molecular format for drug development as well as other applications, ranging from research …

Peptides show high promise in the targeting and intracellular delivery of next-generation bio-
and nano-therapeutics. However, the proteolytic susceptibility of peptides is one of the major …

Introduction: To discover and develop a peptide, protein, or antibody into a drug requires
overcoming multiple challenges to obtain desired properties. Proteolytic stability is one of …

Mounting evidence indicates that the neuropeptide FF (NPFF) system is involved in the side
effects of opioid usage, including antinociceptive tolerance, hyperalgesia, abuse …

We previously reported that a multifunctional opioid/neuropeptide FF receptor agonist, DN-9,
achieved peripherally restricted analgesia with reduced side effects. To develop stable and …

Diastereoselective Anomeric C(sp3)‐H Cyclization Towards the Design of New Cyclophane‐Braced
Glycopeptides Page 1 Angewandte Eine Zeitschrift der Gesellschaft Deutscher Chemiker …

Antimicrobial peptides (AMPs) are considered a promising therapeutic approach against
multi-drug resistant microorganisms. Besides their advantages, there are limitations to be …

Cyclic peptides present a robust platform for drug design, offering high specificity and
stability due to their conformationally constrained structures. In this study, we introduce an …

Abstract The bacterial toxin CcdB (Controller of Cell death or division B) targets DNA
Gyrase, an essential bacterial topoisomerase, which is also the molecular target for …

We introduce novel lysine-stapled peptide inhibitors targeting p53-MDM2/MDMX
interactions. Leveraging the model peptides pDI (LTFEHYWAQLTS) and PMI-M3 …