Leishmaniasis drug discovery: recent progress and challenges in assay development
Highlights•Leishmaniasis remains a neglected tropical disease, with a high unmet medical
need.•Therapeutic efficacy varies depending on the species of Leishmania parasite.•Leads …
need.•Therapeutic efficacy varies depending on the species of Leishmania parasite.•Leads …
Serodiagnosis of leishmaniasis
K Kar - Critical reviews in microbiology, 1995 - Taylor & Francis
Leishmaniasis is a spectrum of diseases ranging in severity from cutaneous (CL), post-kala-
azar dermal (PKDL), and diffuse cutaneous (DCL) to mucocutaneous (MCL) and visceral …
azar dermal (PKDL), and diffuse cutaneous (DCL) to mucocutaneous (MCL) and visceral …
[HTML][HTML] Co‐amplification of the γ‐glutamylcysteine synthetase gene gsh1 and of the ABC transporter gene pgpA in arsenite‐resistant Leishmania tarentolae
K Grondin, A Haimeur, R Mukhopadhyay… - The EMBO …, 1997 - embopress.org
Resistance to the oxyanion arsenite in the parasite Leishmania is multifactorial. We have
described previously the frequent amplification of the ABC transporter gene pgpA, the …
described previously the frequent amplification of the ABC transporter gene pgpA, the …
Oral delivery of ursolic acid-loaded nanostructured lipid carrier coated with chitosan oligosaccharides: Development, characterization, in vitro and in vivo assessment …
Visceral leishmaniasis (VL) is a life-threatening disease caused by Leishmania donovani
due to uncontrolled parasitisation of liver, spleen, and bone marrow. Ursolic acid (UA), a …
due to uncontrolled parasitisation of liver, spleen, and bone marrow. Ursolic acid (UA), a …
Development and evaluation of a cedrol-loaded nanostructured lipid carrier system for in vitro and in vivo susceptibilities of wild and drug resistant Leishmania …
N Kar, S Chakraborty, AK De, S Ghosh… - European Journal of …, 2017 - Elsevier
Leishmaniasis is an epidemic in various countries, and the parasite Leishmania donovani is
developing resistance against available drugs. In the present study the antileishmanial …
developing resistance against available drugs. In the present study the antileishmanial …
[PDF][PDF] Leishmania spp: completely defined medium without serum and macromolecules (CDM/LP) for the continuous in vitro cultivation of infective promastigote forms.
T Merlen, D Sereno, N Brajon, F Rostand… - The American journal of …, 1999 - Citeseer
The elimination of serum or of serum-derived macromolecules that supplant the fetal calf
serum requirement from Leishmania culture media could decrease costs and improve the …
serum requirement from Leishmania culture media could decrease costs and improve the …
Oleanolic acid loaded poly lactic co-glycolic acid-vitamin E TPGS nanoparticles for the treatment of Leishmania donovani infected visceral leishmaniasis
S Ghosh, N Kar, T Bera - International journal of biological macromolecules, 2016 - Elsevier
Oleanolic acid (OA) has low aqueous solubility and low permeability, which results poor
bioavailability. To surmount the inadequacy, our aim was to fabricate oleanolic acid loaded …
bioavailability. To surmount the inadequacy, our aim was to fabricate oleanolic acid loaded …
In Vitro Susceptibilities of Wild and Drug Resistant Leishmania donovani Amastigote Stages to Andrographolide Nanoparticle: Role of Vitamin E Derivative TPGS for …
Visceral leishmaniasis (VL) is a chronic protozoan infection in humans associated with
significant global morbidity and mortality. There is an urgent need to develop drugs and …
significant global morbidity and mortality. There is an urgent need to develop drugs and …
The Leishmania donovani LD1 locus gene ORFG encodes a biopterin transporter (BT1)
C Lemley, S Yan, VS Dole, R Madhubala… - Molecular and …, 1999 - Elsevier
We have previously described two genes, ORFF and ORFG, from the LD1 locus near one
telomere of chromosome 35, which are frequently amplified in Leishmania isolates. In …
telomere of chromosome 35, which are frequently amplified in Leishmania isolates. In …
Amphotericin B-loaded mannose modified poly (d, l-lactide-co-glycolide) polymeric nanoparticles for the treatment of visceral leishmaniasis: in vitro and in vivo …
It is evident from many previous research works that the mannose receptors on the surface
of macrophages play an important role in the process of phagocytosis and they are over …
of macrophages play an important role in the process of phagocytosis and they are over …