Amorphous solid dispersions: role of the polymer and its importance in physical stability and in vitro performance

Q Shi, H Chen, Y Wang, R Wang, J Xu, C Zhang - Pharmaceutics, 2022 - mdpi.com
Amorphous solid dispersions stabilized by one or more polymer (s) have been widely used
for delivering amorphous drugs with poor water solubilities, and they have gained great …

Continuous manufacturing of cocrystals using 3d-printed microfluidic chips coupled with spray coating

A Kara, D Kumar, AM Healy, A Lalatsa, DR Serrano - Pharmaceuticals, 2023 - mdpi.com
Using cocrystals has emerged as a promising strategy to improve the physicochemical
properties of active pharmaceutical ingredients (APIs) by forming a new crystalline phase …

Development, optimization and pharmacokinetic evaluation of biphasic extended-release osmotic drug delivery system of trospium chloride for promising application …

R Gundu, S Pekamwar, S Shelke, D Kulkarni… - Future Journal of …, 2021 - Springer
Background The research was aimed with an approach to formulate biphasic extended-
release system of trospium chloride resulting in controlled release of drug up to 24 h with …

Molecular Cocrystals with Hydrogen-Bonded Polymeric Structures and Polarized Luminescence

JY Zhao, FF Xu, ZQ Li, ZL Gong, YW Zhong, J Yao - Materials, 2022 - mdpi.com
Crystalline materials with appealing luminescent properties are attractive materials for
various optoelectronic applications. The in situ bicomponent reaction of 1, 2 …

Dehydroepiandrosterone cocrystals with improved solubility and bioavailability

Y Jiang, Y Cheng, M Xia, B Zhang, Q Ding, L Lu… - Pharmaceutics, 2022 - mdpi.com
Dehydroepiandrosterone (DHEA) is an FDA-approved food supplement used as an assisted
reproductive sex hormone. The bioavailability is severely limited by its poor solubility (23 …

[PDF][PDF] Development and evaluation of bicomponent cocrystals of aceclofenac for efficient drug delivery with enhanced solubility and improved dissolution

SS Pekamwar, DA Kulkarni - Indian Drugs, 2021 - researchgate.net
This research work was intended to improve the solubility and dissolution of aceclofenac by
the development of bicomponent cocrystals. Bicomponent cocrystals of aceclofenac were …

Drug release from carrier systems comprising meloxicam crystals formed by impregnation-evaporation

P Zámostný, M Drahozal, O Švehla, S Römerová… - Crystals, 2023 - mdpi.com
The impregnation of poorly water-soluble drug onto the surface of a suitable pharmaceutical
excipient, used as a hydrophilic carrier, can lead to the preparation of systems with improved …

Continuous microfluidic manufacture of cocrystals using 3D printed chips coupled with spray coating

A Kara, D Kumar, AM Healy, K Lalatsa… - …, 2023 - strathprints.strath.ac.uk
Using cocrystals has emerged as a promising strategy to improve the physicochemical
properties of active pharmaceutical ingredients (APIs) by forming a new crystalline phase …

The effects of ascorbic acid and tartaric acid on pioglitazone hydrochloride solubility

D Karimkhani, E Rahimpour, A Jouyban… - … and Chemistry of …, 2024 - Taylor & Francis
Application of two coformers, l-tartaric acid (TA) and ascorbic acid (AA) was evaluated on the
solubility of pioglitazone hydrochloride (PGZ. HCl). Solid dispersions were prepared using …

Development and pharmacokinetic evaluation of osmotically controlled drug delivery system of Valganciclovir HCl for potential application in the treatment of CMV …

R Gundu, S Pekamwar, S Shelke, D Kulkarni… - Drug Delivery and …, 2022 - Springer
Valganciclovir HCl (VGH) is the widely used drug for the treatment of cytomegalovirus (CMV)
retinitis infection with an induction dose of 900 mg per oral (po) twice a day and a …