Deazapurine (pyrrolo [2, 3‐d] pyrimidine) nucleosides are important analogues of biogenic
purine nucleosides with diverse biological activities. Replacement of the N7 atom with a …

Quantum mechanical (QM) methods have been gaining importance in structure‐based drug
design where a reliable description of protein‐ligand interactions is of utmost significance …

Cyclic dinucleotides (CDNs) are second messengers that activate stimulator of interferon
genes (STING). The cGAS-STING pathway plays a promising role in cancer immunotherapy …

A series of 7-deazaadenine ribonucleosides bearing alkyl, alkenyl, alkynyl, aryl, or hetaryl
groups at position 7 as well as their 5′-O-triphosphates and two types of monophosphate …

The nucleoside antibiotic tubercidin displays strong activity against different target
organisms, but it is notoriously toxic to mammalian cells. The effects of tubercidin against T …

Three series of isomeric pyrrolo-and furo-fused 7-deazapurine ribonucleosides were
synthesized and screened for cytostatic and antiviral activity. The synthesis was based on …

Two isomeric series of new thieno-fused 7-deazapurine ribonucleosides (derived from 4-
substituted thieno [2′, 3′: 4, 5] pyrrolo [2, 3-d] pyrimidines and thieno [3′, 2′: 4, 5] …

Adenosine kinase (AdK) inhibitors raise endogenous adenosine levels, particularly in
disease states, and have potential for treatment of seizures, neurodegeneration, and …

Trichomoniasis is the most common nonviral sexually transmitted disease in humans, but
treatment options are limited. Here, we report a resorufin-based drug sensitivity assay for …

(2-Thienyl)-7-deazaadenosine (AB61) showed nanomolar cytotoxic activities against
various cancer cell lines but only mild (micromolar) activities against normal fibroblasts. The …