The liver has a critical role in regulating host metabolism, immunity, detoxification, and
homeostasis. Proper liver function is essential for host health, and dysregulation of hepatic …

Organoid cultures offer a valuable platform for studying organ-level biology, allowing for a
closer mimicry of human physiology compared to traditional two-dimensional cell culture …

Cholestatic liver injuries, characterized by regional damage around the bile ductular region,
lack curative therapies and cause considerable mortality. Here we generated a high …

The liver is a complex organ with the ability to regenerate itself in response to injury.
However, several factors can contribute to liver damage beyond repair. Liver injury can be …

Unlike most cancers, adrenocortical carcinomas (ACCs) are more frequent in women than in
men, but the underlying mechanisms of this sexual dimorphism remain elusive. Here, we …

The transmembrane E3 ligases RNF43 and ZNRF3 perform key tumour suppressor roles by
inducing endocytosis of members of the Frizzled (FZD) family, the primary receptors for …

The liver possesses a unique regenerative ability to restore its original mass, in this regard,
partial hepatectomy (PHx) and partial liver transplantation (PLTx) can be executed smoothly …

Digestive system diseases arise primarily through the interplay of genetic and environmental
influences; there is an urgent need in elucidating the pathogenic mechanisms of these …

Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer,
accounting for 85% to 90% of all liver cancer cases. It is a hepatocyte-derived primary tumor …

Liver cancer is the fifth most widespread in the world, with a high fatality rate and poor
prognosis. However, surgicalresction, thermal/radiofrequencyablation, chemo …