The essential amino acid tryptophan is not only a precursor of serotonin but is also
degraded to several other neuroactive compounds, including kynurenic acid, 3 …

Various pathologies of the central nervous system (CNS) are accompanied by alterations in
tryptophan metabolism. The main metabolic route of tryptophan degradation is the …

Tryptophan is an essential amino acid that can be metabolised through different pathways, a
major route being the kynurenine pathway. The first enzyme of the pathway, indoleamine-2 …

Aims The family of kynurenine pathway (KP) metabolites includes compounds produced
along two arms of the path and acting in clearly opposite ways. The equilibrium between …

Understanding the neurochemical basis for cognitive function is one of the major goals of
neuroscience, with a potential impact on the diagnosis, prevention and treatment of a range …

The synthesis of NAD (or NADP) from tryptophan involves a series of enzymes and the
formation of a number of intermediates which are collectively calledkynurenines.'In the late …

In just under 20 years the kynurenine family of compounds has developed from a group of
obscure metabolites of the essential amino acid tryptophan into a source of intensive …

Kynurenic acid is a tryptophan metabolite provided with antagonist activity on ionotropic
glutamate and α7 nicotinic acetylcholine receptors. We noticed that in rats with a dialysis …

Under normal physiological conditions, the kynurenine pathway (KP) plays a critical role in
generating cellular energy and catabolizing tryptophan. Under inflammatory conditions …

It is usually assumed that kynurenic acid (KYNA) modifies neuronal function because it
antagonizes the glycine site of the NMDA receptors and/or the neuronal cholinergic α7 …