Despite great international efforts, malaria still inflicts an enormous toll on human lives,
especially in Africa. Throughout history, antimalarial medicines have been one of the most …

Traditional Chinese medicine commands a unique position among all traditional medicines
because of its 5000 years of history. Our own interest in natural products from traditional …

Covering: 31st December 2004Natural product and natural product-derived compounds that
are being evaluated in clinical trials or in registration (current 31 December 2004) have …

Interest in green chemistry and clean processes has grown so much in recent years that
topics such as fluorous biphasic catalysis, metal organic frameworks, and process …

Malaria has been a global epidemic health threat since ancient times. It still claims roughly
half a million lives every year in this century. Artemisinin and its derivatives, are frontline …

Propargylamines have been synthesized by a gold (III) salen complex-catalyzed three-
component coupling reaction of aldehydes, amines, and alkynes in water in excellent yields …

Since ancient times, humankind has had to struggle against the persistent onslaught of
pathogenic microorganisms. Nowadays, malaria is still the most important infectious disease …

Diseases caused by tropical parasites affect hundreds of millions of people worldwide but
have been largely neglected for drug development because they affect poor people in poor …

Artemisinins form the most important class of antimalarial currently available, particularly
because they are effective against parasites resistant to almost all the other classes. Their …

The artemisinins are the most potent and rapidly acting antimalarial drugs. In response to
the global threat of multidrug-resistant malaria, they are now widely used in combination …