Notch signaling is an evolutionarily highly conserved signaling mechanism, but in contrast to
signaling pathways such as Wnt, Sonic Hedgehog, and BMP/TGF-β, Notch signaling occurs …

Myc is a nuclear transcription factor that mainly regulates cell growth, cell cycle, metabolism,
and survival. Myc family proteins contain c-Myc, n-Myc, and l-Myc. Among them, c-Myc can …

We report a comprehensive molecular characterization of pheochromocytomas and
paragangliomas (PCCs/PGLs), a rare tumor type. Multi-platform integration revealed that …

Notch signaling is evolutionarily conserved and operates in many cell types and at various
stages during development. Notch signaling must therefore be able to generate appropriate …

The discovery of Notch in Drosophila melanogaster nearly a century ago opened the door to
an ever-widening understanding of cellular processes that are controlled or influenced by …

Notch signaling regulates many aspects of metazoan development and tissue renewal.
Accordingly, the misregulation or loss of Notch signaling underlies a wide range of human …

Correct development of the human placenta and its differentiated epithelial cells, syncytial
trophoblasts (STBs) and extravillous trophoblasts (EVTs), is crucial for a successful …

Notch has been linked to β-catenin-dependent tumorigenesis; however, the mechanisms
leading to Notch activation and the contribution of the Notch pathway to colorectal cancer is …

Abstract β-catenin is involved in cell adhesion through catenin-cadherin complexes and as a
transcriptional regulator in the Wnt signaling pathway. Its deregulation is important in the …

The canonical Wnt signaling pathway is pathogenic in a variety of cancers. We previously
identified aberrant expression of the Wnt pathway transcription factor and target gene …