Short telomeres confer risk of degenerative diseases. Chronic psychological stress can lead
to disease through many pathways, and research from in vitro studies to human longitudinal …

Telomere attrition is considered a hallmark of ageing. Untangling the proximate causes of
telomere attrition may therefore reveal important aspects about the ageing process. In a …

Biologists have long appreciated the critical role that energy turnover plays in understanding
variation in performance and fitness among individuals. Whole-organism metabolic studies …

Mitochondria are membrane organelles present in almost all eukaryotic cells. In addition to
their well-known role in energy production, mitochondria regulate central cellular processes …

Major depressive disorder (MDD) is highly prevalent in adolescents and is a major risk factor
for suicidality. Recent evidence shows that accelerated cellular senescence/aging is …

Mitochondrial stress may be a secondary contributor to muscle weakness in inherited
muscular dystrophies. Duchenne muscular dystrophy has received the majority of attention …

It is well known that oxidative stress is a major cause of DNA damage and telomere attrition.
Most endogenous reactive oxygen species (ROS) are produced in the mitochondria …

Aging is characterized by functional decline occurring alongside changes to several
hallmarks of aging. One of the hallmarks includes attrition of repeated DNA sequences …

A fundamental issue in the metabolic field is whether it is possible to understand underlying
mechanisms that characterize individual variation. Whole-animal performance relies on …

Research on telomeres in the fields of ecology and evolution has been rapidly expanding
over the last two decades. This has resulted in the formulation of a multitude of, often name …