Whilst the inhaled route is the first line administration method in the management of asthma,
it is well documented that patients can have problems adopting the correct inhaler technique …

Patients with severe refractory asthma pose a major healthcare problem. Over the last
decade it has become increasingly clear that, for the development of new targeted therapies …

Asthma is one of the most common chronic diseases of childhood. Allergen sensitization
and high frequencies of comorbid allergic diseases are characteristic of severe asthma in …

Adherence to daily inhaled corticosteroid therapy is a key determinant of asthma control.
Therefore, improving adherence to inhaled corticosteroids is the most effective method …

Background Results from phase III clinical trials in adults and phase II clinical trials in
children and adolescents demonstrate that tiotropium is an effective treatment when added …

Asthma is the most common chronic disease in childhood. Overweight and obesity are
included among the comorbidities considered in patients with difficult-to-treat asthma …

Background Studies in adults and adolescents have demonstrated that tiotropium is
efficacious as an add-on therapy to inhaled corticosteroids (ICSs) with or without other …

Most children with asthma have their disease easily controlled if low‐dose inhaled
corticosteroids (ICSs) are regularly and correctly administered. If a child presents with …

The causes of severe childhood asthma are poorly understood. Our aim was to define global
patterns of gene expression in children with severe therapy-resistant and controlled asthma …

Severe asthma is a relatively uncommon condition in children but one which causes
morbidity, occasionally mortality, and is a challenging condition to manage. There are …