Enabling high structural specificity to lipidomics by coupling photochemical derivatization with tandem mass spectrometry

X Ma, W Zhang, Z Li, Y Xia… - Accounts of chemical …, 2021 - ACS Publications
Conspectus Lipids have pivotal roles in many biological processes, including energy
storage, signal transduction, and plasma membrane formation. A disruption of lipid …

Recent advances in on-site mass spectrometry analysis for clinical applications

X Zhou, W Zhang, Z Ouyang - TrAC Trends in Analytical Chemistry, 2022 - Elsevier
In recent years, mass spectrometry (MS) is increasingly attracting interests for clinical
applications, which also calls for technical innovations to make a transfer of MS from …

A review of portable high-performance liquid chromatography: the future of the field?

F Rahimi, S Chatzimichail, A Saifuddin, AJ Surman… - Chromatographia, 2020 - Springer
There is a growing need for chemical analyses to be performed in the field, at the point of
need. Tools and techniques often found in analytical chemistry laboratories are necessary in …

Miniature mass spectrometers and their potential for clinical point‐of‐care analysis

Y Zhai, X Fu, W Xu - Mass Spectrometry Reviews, 2024 - Wiley Online Library
Mass spectrometry (MS) has become a powerful technique for clinical applications with high
sensitivity and specificity. Different from conventional MS diagnosis in laboratory, point‐of …

High-throughput analysis of tissue microarrays using automated desorption electrospray ionization mass spectrometry

NM Morato, HM Brown, D Garcia, EH Middlebrooks… - Scientific reports, 2022 - nature.com
Tissue microarrays (TMAs) are commonly used for the rapid analysis of large numbers of
tissue samples, often in morphological assessments but increasingly in spectroscopic …

Applications of mass spectrometry for clinical diagnostics: the influence of turnaround time

DJ Swiner, S Jackson, BJ Burris… - Analytical …, 2019 - ACS Publications
The activities of modern society are centered on an obsessive relationship with time, where
we put emphasis on speed. Therefore, turnaround times (also response times or waiting …

Handheld mass spectrometer with intelligent adaptability for on-site and point-of-care analysis

B Jiao, H Ye, X Liu, J Bu, J Wu, W Zhang… - Analytical …, 2021 - ACS Publications
The development of miniature mass spectrometry (MS) systems with simple analysis
procedures is important for the transition of applying MS analysis outside traditional …

Development of a miniature mass spectrometry system for point-of-care analysis of lipid isomers based on ozone-induced dissociation

X Liu, B Jiao, W Cao, X Ma, Y Xia, SJ Blanksby… - Analytical …, 2022 - ACS Publications
Disorder of lipid homeostasis is closely associated with a variety of diseases. Although mass
spectrometry (MS) approaches have been well developed for the characterization of lipids, it …

Profiling of urine carbonyl metabolic fingerprints in bladder cancer based on ambient ionization mass spectrometry

Y Li, L Jiang, Z Wang, Y Wang, X Cao, L Meng… - Analytical …, 2022 - ACS Publications
The diagnosis of bladder cancer (BC) is currently based on cystoscopy, which is invasive
and expensive. Here, we describe a noninvasive profiling method for carbonyl metabolic …

Differentiating enantiomers by directional rotation of ions in a mass spectrometer

X Zhou, Z Wang, S Li, X Rong, J Bu, Q Liu, Z Ouyang - Science, 2024 - science.org
Conventional mass spectrometry does not distinguish between enantiomers, or mirror-
image isomers. Here we report a technique to break the chiral symmetry and to differentiate …