Cancer neuroscience: State of the field, emerging directions

F Winkler, HS Venkatesh, M Amit, T Batchelor, IE Demir… - Cell, 2023 - cell.com
The nervous system governs both ontogeny and oncology. Regulating organogenesis
during development, maintaining homeostasis, and promoting plasticity throughout life, the …

Voltage-gated sodium channels in cancers

H Liu, J Weng, CLH Huang, AP Jackson - Biomarker Research, 2024 - Springer
Voltage-gated sodium channels (VGSCs) initiate action potentials in electrically excitable
cells and tissues. Surprisingly, some VGSC genes are aberrantly expressed in a variety of …

Bioelectricity of non-excitable cells and multicellular pattern memories: Biophysical modeling

J Cervera, M Levin, S Mafe - Physics Reports, 2023 - Elsevier
Cells must coordinate their individual activities toward multicellular goals, which requires
efficient information processing mechanisms. Bioelectrical signals encode instructive rules …

Targeting tumor microenvironment by metal peroxide nanoparticles in cancer therapy

SN Mbugua - Bioinorganic Chemistry and Applications, 2022 - Wiley Online Library
Solid tumors have a unique tumor microenvironment (TME), which includes hypoxia, low
acidity, and high hydrogen peroxide and glutathione (GSH) levels, among others. These …

KCNK1 promotes proliferation and metastasis of breast cancer cells by activating lactate dehydrogenase A (LDHA) and up-regulating H3K18 lactylation

X Hou, J Ouyang, L Tang, P Wu, X Deng, Q Yan… - Plos …, 2024 - journals.plos.org
Breast cancer is the most prevalent malignancy and the most significant contributor to
mortality in female oncology patients. Potassium Two Pore Domain Channel Subfamily K …

Nanotechnology and Cancer Bioelectricity: Bridging the Gap Between Biology and Translational Medicine

R Moreddu - Advanced Science, 2024 - Wiley Online Library
Bioelectricity is the electrical activity that occurs within living cells and tissues. This activity is
critical for regulating homeostatic cellular function and communication, and disruptions of …

Electrical excitability of cancer cells—CELEX model updated

MBA Djamgoz - Cancer and Metastasis Reviews, 2024 - Springer
The normal functioning of every cell in the body depends on its bioelectric properties and
many diseases are caused by genetic and/or epigenetic dysregulation of the underlying ion …

Potassium channels: Novel targets for tumor diagnosis and chemoresistance

M Li, P Tian, Q Zhao, X Ma, Y Zhang - Frontiers in Oncology, 2023 - frontiersin.org
In recent years, the role of potassium channels in tumors has been intensively studied.
Potassium channel proteins are widely involved in various physiological and pathological …

[HTML][HTML] Potassium channels, tumorigenesis and targeted drugs

C Xia, C Liu, S Ren, Y Cai, Q Zhang, C Xia - Biomedicine & …, 2023 - Elsevier
Potassium channels play an important role in human physiological function. Recently,
various molecular mechanisms have implicated abnormal functioning of potassium …

The distinguishing electrical properties of cancer cells

E Di Gregorio, S Israel, M Staelens, G Tankel… - Physics of life …, 2022 - Elsevier
In recent decades, medical research has been primarily focused on the inherited aspect of
cancers, despite the reality that only 5–10% of tumours discovered are derived from genetic …