Dendritic cells: regulators of alloimmunity and opportunities for tolerance induction

AE Morelli, AW Thomson - Immunological reviews, 2003 - Wiley Online Library
Dendritic cells (DCs) are uniquely well‐equipped antigen‐presenting cells (APCs) regarded
classically as sentinels of the immune response, which induce and regulate T‐cell reactivity …

Development of dendritic cell-based immunotherapy for autoimmunity

CMU Hilkens, JD Isaacs… - International reviews of …, 2010 - Taylor & Francis
Dendritic cells are professional antigen-presenting cells that maintain immune tolerance to
self-antigens by deleting or controlling the pathogenicity of auto-reactive T-cells. Dendritic …

In vivo imaging platform for tracking immunotherapeutic cells

ET Ahrens, R Flores, H Xu, PA Morel - Nature biotechnology, 2005 - nature.com
Cellular therapeutics show great promise for the treatment of disease, but few noninvasive
techniques exist for monitoring the cells after administration. Here we present a magnetic …

Dendritic Cells Promote Macrophage Infiltration and Comprise a Substantial Proportion of Obesity-Associated Increases in CD11c+ Cells in Adipose Tissue and Liver

M Stefanovic-Racic, X Yang, MS Turner, BS Mantell… - Diabetes, 2012 - Am Diabetes Assoc
Obesity-associated increases in adipose tissue (AT) CD11c+ cells suggest that dendritic
cells (DC), which are involved in the tissue recruitment and activation of macrophages, may …

Human mesenchymal stem cells and derived extracellular vesicles induce regulatory dendritic cells in type 1 diabetic patients

E Favaro, A Carpanetto, C Caorsi, M Giovarelli… - Diabetologia, 2016 - Springer
Aims/hypothesis Mesenchymal stem cells (MSCs) can exert an immunosuppressive effect
on any component of the immune system, including dendritic cells (DCs), by direct contact …

CCR9 expression defines tolerogenic plasmacytoid dendritic cells able to suppress acute graft-versus-host disease

H Hadeiba, T Sato, A Habtezion, C Oderup, J Pan… - Nature …, 2008 - nature.com
Dendritic cells (DCs) are'professional'antigen-presenting cells that are key in the regulation
of immune responses. Here we characterize a unique subset of tolerogenic DCs that …

Activation of CD1d-restricted T cells protects NOD mice from developing diabetes by regulating dendritic cell subsets

YN Naumov, KS Bahjat, R Gausling… - Proceedings of the …, 2001 - National Acad Sciences
CD1d-restricted invariant NKT (iNKT) cells are immunoregulatory cells whose loss
exacerbates diabetes in nonobese diabetic (NOD) female mice. Here, we show that the …

Dominant role of antigen dose in CD4+ Foxp3+ regulatory T cell induction and expansion

MS Turner, LP Kane, PA Morel - The Journal of Immunology, 2009 - journals.aai.org
The definitions of tolerogenic vs immunogenic dendritic cells (DC) remain controversial.
Immature DC have been shown to induce T regulatory cells (Treg) specific for foreign and …

1, 25-Dihydroxyvitamin D3 promotes tolerogenic dendritic cells with functional migratory properties in NOD mice

GB Ferreira, CA Gysemans, J Demengeot… - The Journal of …, 2014 - journals.aai.org
The biologically active form of vitamin D, 1, 25-dihydroxyvitamin D 3 [1, 25 (OH) 2 D 3], is
able to promote the generation of tolerogenic mature dendritic cells (mDCs) with an …

Receptor‐mediated endocytosis of iron‐oxide particles provides efficient labeling of dendritic cells for in vivo MR imaging

ET Ahrens, M Feili‐Hariri, H Xu… - … in Medicine: An …, 2003 - Wiley Online Library
Dendritic cells (DCs) function as antigen presenting cells in vivo and play a fundamental role
in numerous diseases. New methods are described for high‐efficiency intracellular labeling …