TNF (tumor necrosis factor) is both a pro-inflammatory and anti-inflammatory cytokine that is
central to the development of autoimmune disease, cancer, and protection against infectious …

Cytokines related to tumor necrosis factor (TNF) provide a communication network essential
for coordinating multiple cell types into an effective host defense system against pathogens …

Tumor necrosis factor (TNF) is a central regulator of immunity. Due to its dominant pro-
inflammatory effects, drugs that neutralize TNF were developed and are clinically used to …

Immune checkpoint inhibitors (ICIs) are effective in the treatment of patients with advanced
cancer and have emerged as a pillar of standard cancer care. However, their use is …

Treatments that block tumour necrosis factor (TNF) have major beneficial effects in several
autoimmune and rheumatic diseases, including rheumatoid arthritis. However, some …

Foxp3+ T-regulatory cells (Tregs) normally serve to attenuate immune responses and are
key to maintenance of immune homeostasis. Over the past decade, Treg cells have become …

Several lines of evidence indicate the instability of CD4+ Foxp3+ regulatory T cells (Tregs).
We have therefore investigated means of promoting the stability of Tregs. In this study, we …

The first Food and Drug Administration-(FDA)-approved drugs were small, chemically-
manufactured and highly active molecules with possible off-target effects, followed by …

Major barriers to cancer therapy include the lack of selective inhibitors of regulatory T cells
(Tregs) and the lack of broadly applicable ways to directly target tumors through frequently …

Chronic plaque psoriasis is a common debilitating skin disease. The identification of the
pathogenic role of the TNF/IL-23/TH17 pathway has enabled the development of targeted …