Aktynomycyna D jest znanym antybiotykiem z grupy aktynomycyn, wykazującym dużą
aktywność przeciwbakteryjną i przeciwnowotworową. W 1954 r. została wprowadzona do …

Plants, marine organisms, and microorganisms have evolved complex chemical defense
and signaling systems that are designed to protect them from predators and provide other …

The X‐ray diffraction experiments on peptides and related molecules which have been
carried out in Western Europe, except Italy, in the last eight years are reviewed. The crystal …

The crystal structures of the 2: 1 complex of the self-complementary DNA octamer d
(GAAGCTTC) with actinomycin D has been determined at 3.0 Å resolution. This is the first …

The potent anticancer drug actinomycin D (ActD) functions by intercalating into DNA at GpC
sites, thereby interrupting essential biological processes including replication and …

The antitumor drug actinomycin D intercalates into DNA and strongly inhibits RNA
transcription at very low concentration. Two independent structures of d (GAAGCTTC) 2 …

Actinomycin D (ActD), a well known transcription inhibitors, has been widely reported to
induce cell apoptosis in several types of tumor cells by inhibiting the anti-apoptotic gene …

Summary The actinomycin-Dd (A1-A2-A3-G4-C5-T6-T7-T8) complex (1 drug per duplex)
has been generated in aqueous solution and its structure characterized by a combined …

Molecular models of the complexes between actinomycin D and 14 different DNA hexamers
were built based on the X-ray crystal structure of the actinomycin–d (GAAGCTTC) 2 …

We have employed a combination of temperature-dependent UV absorption spectroscopy,
circular dichroism, and batch calorimetry to characterize the binding of actinomycin D to a …