Sulfur (S VI) based moieties, especially, the sulfonyl or sulfonamide based analogues have
showed a variety of pharmacological properties, and its derivatives propose a high degree …

The rise of drug-resistance has made the deserted clinical requirement to improve of new
classes of antibiotics agents. The development of antibacterial agents with the novel method …

Since the advent of penicillin, humans have known about and explored the phenomenon of
bacterial inhibition via antibiotics. However, with changes in the global environment and the …

The multidrug resistance developed in many organisms due to the prolonged use of
antibiotics has been an increasing global health crisis. Klebsiella pneumoniae is a causal …

Aminothiophenes are important five-membered heterocyclic building blocks in organic
synthesis, and the chemistry of these small molecules is still developing based on the …

Abstract Ethyl 2‐acrylamido‐4, 5, 6, 7‐tetrahydrobenzo [b] thiophene‐3‐carboxylate as well
as its corresponding bis‐derivatives, 5–10, with aliphatic linkers were synthesized, fully …

With antibiotic resistance mechanisms increasing in diversity and spreading among
bacterial pathogens, the development of new classes of antibacterial agents against …

MurF ligase catalyzes the final cytoplasmic step of bacterial peptidoglycan biosynthesis and,
as such, is a validated target for therapeutic intervention. Herein, we performed molecular …

The widespread emergence of resistant bacterial strains is becoming a serious threat to
public health. This thus signifies the need for the development of new antibacterial agents …

Thiophene, as a member of the group of five‐membered heterocycles containing one
heteroatom, is one of the simplest heterocyclic systems. Many synthetic strategies allow the …