Acute myeloid leukemia (AML) is a heterogeneous group of diseases characterized by
uncontrolled proliferation of hematopoietic stem cells in the bone marrow. Malignant cell …

Acute myeloid leukemia (AML) is one of the most common and life-threatening leukemias. A
highly diverse and flexible metabolism contributes to the aggressiveness of the disease that …

We report that tumor cells without mitochondrial DNA (mtDNA) show delayed tumor growth,
and that tumor formation is associated with acquisition of mtDNA from host cells. This leads …

Acute myeloid leukemia (AML) is a group of hematological malignancies with high
heterogeneity. There is an increasing need to improve the risk stratification of AML patients …

Caveolins are a family of membrane-bound scaffolding proteins that compartmentalize and
negatively regulate signal transduction. Recent studies have implicated a loss of caveolin-1 …

Autophagy sustains cellular homeostasis and metabolism in numerous diseases. By
regulating cancer metabolism, both tumor and microenvironmental autophagy promote …

Rapidly proliferating leukemic progenitor cells consume substantial glucose, which may
lead to glucose insufficiency in bone marrow. We show that acute myeloid leukemia (AML) …

Decreased autophagy contributes to malignancies; however, it is unclear how autophagy
has an impact on tumor growth. Acute myeloid leukemia (AML) is an ideal model to address …

Despite recent advancements in the treatment of hematologic malignancies and the
emergence of newer and more sophisticated therapeutic approaches such as …

Alterations in metabolic activities are cancer hallmarks that offer a wide range of new
therapeutic opportunities. Here we decipher the interplay between mTORC1 activity and …