The production of erythropoietin (EPO), the main regulator of erythroid differentiation, is
regulated by hypoxia-inducible factor (HIF). HIF2α seems to be the principal regulator of …

Every cell in the body requires oxygen for its functioning, in virtually every animal, and a
tightly regulated system that balances oxygen supply and demand is therefore fundamental …

Erythropoiesis is a complex process driving the production of red blood cells. During
homeostasis, adult erythropoiesis takes place in the bone marrow and is tightly controlled by …

Diabetic retinopathy (DR) is a diabetic complication that results in visual impairment and
relevant retinal diseases. Current therapeutic strategies on DR primarily focus on …

The regulation of oxygen (O2) levels is crucial in embryogenesis and adult life, as O2
controls a multitude of key cellular functions. Low oxygen levels (hypoxia) are relevant for …

Objective—Pathological angiogenesis, such as exuberant retinal neovascularization during
proliferative retinopathies, involves endothelial responses to ischemia/hypoxia and oxidative …

The uncontrolled growth of blood vessels is a major pathological factor in human eye
diseases that can result in blindness. This effect is termed ocular neovascularization and is …

Neovascular retinal degeneration is a leading cause of blindness in advanced countries.
Anti-vascular endothelial growth factor (VEGF) drugs have been used for neovascular retinal …

Glucocorticoid-induced (GC) and hypoxia-induced transcriptional responses play an
important role in tissue homeostasis and in the regulation of cellular responses to stress and …

Cellular senescence, a state of permanent cell cycle arrest in response to endogenous and
exogenous stimuli, triggers a series of gradual alterations in structure, metabolism, and …