The heterogeneity of tissue macrophages, in health and in disease, has become
increasingly transparent over the last decade. But with the plethora of data comes a natural …

Cholesterol metabolism produces essential membrane components as well as metabolites
with a variety of biological functions. In the tumour microenvironment, cell-intrinsic and cell …

The concept of targeting cholesterol metabolism to treat cancer has been widely tested in
clinics, but the benefits are modest, calling for a complete understanding of cholesterol …

Naive T cells are actively maintained in a quiescent state that promotes their survival and
persistence. On antigen stimulation, T cells exit quiescence to initiate clonal expansion and …

The maintenance of organismal homeostasis requires partitioning and transport of
biochemical molecules between organ systems, their composite cells, and subcellular …

T cells orchestrate adaptive immunity against pathogens and other immune challenges, but
their dysfunction can also mediate the pathogenesis of cancer and autoimmunity. Metabolic …

Liver X receptors α and β (LXRα and LXRβ) are nuclear receptors with pivotal roles in the
transcriptional control of lipid metabolism. Transcriptional activity of LXRs is induced in …

Cardiovascular disease is the leading cause of death worldwide, both in the general
population and among patients with chronic kidney disease (CKD). In most cases, the …

Dysregulated lipid metabolism represents an important metabolic alteration in cancer. Fatty
acids, cholesterol, and phospholipid are the three most prevalent lipids that act as energy …

Cholesterol plays an important role in cancer development. Both clinical and experimental
studies have found that hypercholesterolemia and a high-fat high-cholesterol diet can affect …