Biocompatible strategies for peptide macrocyclisation
Peptides are increasingly important drug candidates, offering numerous advantages over
conventional small molecules. However, they face significant challenges related to stability …
conventional small molecules. However, they face significant challenges related to stability …
A biocompatible, highly efficient click reaction and its applications
Y Yuan, G Liang - Organic & Biomolecular Chemistry, 2014 - pubs.rsc.org
Herein, we review the development, optimization, applications and potential prospects of a
novel click reaction based on the condensation reaction between 2-cyanobenzothiazole …
novel click reaction based on the condensation reaction between 2-cyanobenzothiazole …
Biocompatible macrocyclization between cysteine and 2-cyanopyridine generates stable peptide inhibitors
Peptides featuring an N-terminal cysteine residue and the unnatural amino acid 3-(2-cyano-
4-pyridyl) alanine (Cpa) cyclize spontaneously in aqueous solution at neutral pH. Cpa is …
4-pyridyl) alanine (Cpa) cyclize spontaneously in aqueous solution at neutral pH. Cpa is …
An Efficient, Site‐Selective and Spontaneous Peptide Macrocyclisation During in vitro Translation
M Liu, R Yoshisada, A Amedi… - … A European Journal, 2023 - Wiley Online Library
Macrocyclisation provides a means of stabilising the conformation of peptides, often
resulting in improved stability, selectivity, affinity, and cell permeability. In this work, a new …
resulting in improved stability, selectivity, affinity, and cell permeability. In this work, a new …
Scope and limitations of the nicking enzyme amplification reaction for the synthesis of base-modified oligonucleotides and primers for PCR
P Ménová, V Raindlova, M Hocek - Bioconjugate chemistry, 2013 - ACS Publications
Enzymatic synthesis of short (10–22 nt) base-modified oligonucleotides (ONs) was
developed by nicking enzyme amplification reaction (NEAR) using Vent (exo-) polymerase …
developed by nicking enzyme amplification reaction (NEAR) using Vent (exo-) polymerase …
Deoxynucleoside triphosphates bearing histamine, carboxylic acid, and hydroxyl residues–synthesis and biochemical characterization
M Hollenstein - Organic & biomolecular chemistry, 2013 - pubs.rsc.org
Modified nucleoside triphosphates (dAHsTP, dUPOHTP, and dCValTP) bearing imidazole,
hydroxyl, and carboxylic acid residues connected to the purine and pyrimidine bases …
hydroxyl, and carboxylic acid residues connected to the purine and pyrimidine bases …
Post-synthesis DNA modifications using a trans-cyclooctene click handle
Post-synthesis DNA modification is a very useful method for DNA functionalization. This is
achieved by using a modified NTP, which has a handle for further modifications, replacing …
achieved by using a modified NTP, which has a handle for further modifications, replacing …
N, S-double labeling of N-terminal cysteines via an alternative conjugation pathway with 2-cyanobenzothiazole
Conjugation of 2-cyanobenzothiazole (CBT) with N-terminal cysteines (NCys) typically gives
a luciferin product. We herein report an alternative reaction pathway leading to an N …
a luciferin product. We herein report an alternative reaction pathway leading to an N …
Post-modification of 2-formylthiophene based heterocyclic azo dyes
D Xu, Z Li, YX Peng, J Geng, HF Qian, W Huang - Dyes and Pigments, 2016 - Elsevier
In order to further adjust the π-conjugated system, solubility and electronic spectrum of 2-
amino-3-cyano-4-chloro-5-formylthiophene based blue colored heterocyclic blue azo dyes …
amino-3-cyano-4-chloro-5-formylthiophene based blue colored heterocyclic blue azo dyes …
Applications of CBT-Cys click reaction: Past, present, and future
M Zhang, G Liang - Science China Chemistry, 2018 - Springer
Herein, we review the development, applications and potential prospects of CBT-Cys click
reaction. This click condensation reaction is based on the condensation reaction between 2 …
reaction. This click condensation reaction is based on the condensation reaction between 2 …