There exists a paucity of structural innovation and limited molecular diversity associated with
molecular frameworks in drug discovery and biomolecular imaging/chemical probe design …

In this review, the history of boron's early use in drugs, and the history of the use of boron
functional groups in medicinal chemistry applications are discussed. This includes …

The introduction of selective COX-2 inhibitors (so-called 'coxibs') has demonstrated
tremendous commercial success due to their claimed lower potential of serious …

The etiology of the majority of human cancers is associated with a myriad of environmental
causes, including physical, chemical, and biological factors. DNA damage induced by such …

Carborane is a carbon-boron molecular cluster that can be viewed as a 3D analog of
benzene. It features special physical and chemical properties, and thus has the potential to …

Data on compounds based on cage structures―boron clusters (polyhedral boron hydrides,
carboranes, metallacarboranes) and compounds of the adamantane series, which possess …

Abstract “There's plenty of room at the bottom”(Richard Feynman, 1959): an invitation for
(metalla) carboranes to enter the (new) field of nanomedicine. For two decades, the number …

Fenoprofen is a widely used nonsteroidal anti‐inflammatory drug (NSAID) against
rheumatoid arthritis, degenerative joint disease, ankylosing spondylitis and gout. Like other …

Alzheimer's disease (AD) is characterized by the progressive disturbance in cognition and
affects approximately 36 million people, worldwide. However, the drugs used to treat this …

In this study, we investigated a novel anti-cancer drug design approach by revisiting
diclofenac-based carborane-substituted prodrugs. The redesigned compounds combine the …