Alzheimer disease (AD) is a major cause of age-related dementia. We do not fully
understand AD aetiology and pathogenesis, but oxidative damage is a key component. The …

The discovery of vitamin E will have its 100th anniversary in 2022, but we still have more
questions than answers regarding the biological functions and the essentiality of vitamin E …

Vitamin A, acting through its metabolite, all-trans-retinoic acid, is a potent transcriptional
regulator affecting expression levels of hundreds of genes through retinoic acid response …

Four tocopherols are available in nature and are absorbed with the diet, but only one RRR-α-
tocopherol satisfies the criteria of being a vitamin. The biological activity of the different …

It is estimated that> 90% of Americans do not consume sufficient dietary vitamin E, as α-
tocopherol, to meet estimated average requirements. What are the adverse consequences …

Abstract α-Tocopherol (α-T) is a required dietary nutrient for humans and thus is a vitamin.
This narrative review focuses on vitamin E structures, functions, biological determinants and …

Alzheimer's disease (AD) is a neurodegenerative disorder representing the major cause of
dementia. It is characterized by memory loss, and cognitive and behavioral decline. In …

Oxidative stress has been established as a well-known pathological condition in several
neurovascular diseases. It starts with increased production of highly oxidizing free-radicals …

With the advancement of in vivo studies and clinical trials, the pathogenesis of
neurodegenerative diseases has been better understood. However, gaps still need to be …

There is currently no accepted classification of autosomal recessive cerebellar ataxias, a
group of disorders characterized by important genetic heterogeneity and complex …