Impact of metformin on neocortical development during pregnancy: Involvement of ERK and p35/CDK5 pathways
Metformin, the most commonly prescribed drug for the treatment of diabetes, is increasingly
used during pregnancy to address various disorders such as diabetes, obesity …
used during pregnancy to address various disorders such as diabetes, obesity …
[HTML][HTML] Initiation of metformin in early pregnancy results in fetal bioaccumulation, growth restriction, and renal dysmorphology in a primate model
E Bolte, T Dean, B Garcia, MD Seferovic… - American journal of …, 2024 - Elsevier
Background In recent years, pragmatic metformin use in pregnancy has stretched to include
prediabetes mellitus, type 2 diabetes mellitus, gestational diabetes mellitus, and (most …
prediabetes mellitus, type 2 diabetes mellitus, gestational diabetes mellitus, and (most …
Single-cell RNA transcriptomics in mice reveals embryonic origin of fibrosis due to maternal obesity
MN Hossain, Y Gao, X Li, L Zhao, X Liu, JM de Avila… - …, 2024 - thelancet.com
Background Over 40% of pregnant women in the USA are obese which negatively affects
fetal development and offspring health. Maternal obesity (MO) leads to fibrotic infiltration in …
fetal development and offspring health. Maternal obesity (MO) leads to fibrotic infiltration in …
Angiogenic Markers in Gestational Diabetes and their Association with Placental Dimensions
S Madiwale, V Kasture, D Sundrani… - Molecular and Cellular …, 2024 - Springer
GDM is an increasing global concern, with its etiology not fully understood, though altered
placental function is likely to play a role. Placental angiogenesis, essential for sufficient …
placental function is likely to play a role. Placental angiogenesis, essential for sufficient …
Metformin administration during pregnancy tends to reduce the risk of gestational diabetes mellitus and improve pregnancy outcomes in previously infertile women …
H Liu, Y Liu, C Wei, S Zhang, Y Xu - Irish Journal of Medical Science (1971 …, 2024 - Springer
Objective Metformin reduces incidences of miscarriage and preterm delivery in polycystic
ovary syndrome (PCOS) women, but its impact on gestational diabetes mellitus (GDM) is …
ovary syndrome (PCOS) women, but its impact on gestational diabetes mellitus (GDM) is …
[HTML][HTML] Epigenetic modulation of cell fate during pancreas development
Epigenetic modifications to DNA and its associated proteins affect cell plasticity and cell fate
restrictions throughout embryonic development. Development of the vertebrate pancreas is …
restrictions throughout embryonic development. Development of the vertebrate pancreas is …
[PDF][PDF] SMFM Papers ajog. org
E Bolte, T Dean, B Garcia, MD Seferovic, K Sauter… - 2024 - researchgate.net
BACKGROUND: In recent years, pragmatic metformin use in pregnancy has stretched to
include prediabetes mellitus, type 2 diabetes mellitus, gestational diabetes mellitus, and …
include prediabetes mellitus, type 2 diabetes mellitus, gestational diabetes mellitus, and …