New biological therapies for multiple myeloma
AL Garfall - Annual Review of Medicine, 2024 - annualreviews.org
Multiple myeloma is a cancer of bone marrow plasma cells that represents approximately
10% of hematologic malignancies. Though it is typically incurable, a remarkable suite of new …
10% of hematologic malignancies. Though it is typically incurable, a remarkable suite of new …
ISB 2001 trispecific T cell engager shows strong tumor cytotoxicity and overcomes immune escape mechanisms of multiple myeloma cells
L Carretero-Iglesia, OJ Hall, J Berret, D Pais… - Nature Cancer, 2024 - nature.com
Despite recent advances in immunotherapies targeting single tumor-associated antigens,
patients with multiple myeloma eventually relapse. ISB 2001 is a CD3+ T cell engager (TCE) …
patients with multiple myeloma eventually relapse. ISB 2001 is a CD3+ T cell engager (TCE) …
HIV-protease inhibitors potentiate the activity of carfilzomib in triple-negative breast cancer
A Besse, L Sedlarikova, L Buechler, M Kraus… - British Journal of …, 2024 - nature.com
Background Resistance to chemotherapy is a major problem in the treatment of patients with
triple-negative breast cancer (TNBC). Preclinical data suggest that TNBC is dependent on …
triple-negative breast cancer (TNBC). Preclinical data suggest that TNBC is dependent on …
Proteasome inhibition enhances the anti-leukemic efficacy of chimeric antigen receptor (CAR) expressing NK cells against acute myeloid leukemia
D Sedloev, Q Chen, JM Unglaub, N Schanda… - Journal of Hematology & …, 2024 - Springer
Background Relapsed and refractory acute myeloid leukemia (AML) carries a dismal
prognosis. CAR T cells have shown limited efficacy in AML, partially due to dysfunctional …
prognosis. CAR T cells have shown limited efficacy in AML, partially due to dysfunctional …
Mechanismy rezistence mnohočetného myelomu-buněčný model
K Rubínová - 2024 - dk.upce.cz
Mnohočetný myelom (MM) je druhé nejčastější hematologické nádorové onemocnění,
zpusobené abnormální proliferací jednoho nebo více klonu plazmatických buněk a jejich …
zpusobené abnormální proliferací jednoho nebo více klonu plazmatických buněk a jejich …